No drug interactrion have been done for this combination.

But the drug interaction of individual drugs is applicable for this combination

Hypertensive patients with hyperliperdemia

Chronic stable angina with hyperlipidemia

Both the agents are well tolerated.

The common adverse effect experienced was fluid retention, headache, dizziness, abdominal pain, and weakness

Monitoring of patients when on this combination for early detection of hepatoxicity and myopathy is recoomended due to the presence of atorvastatin.

Active liver disease and unexplained persistent elevations of serum transaminase due to the presence of atorvastatin, hypersensitivity and lactation.

Indication-

Hypertensive patients with hyperliperdemia

Chronic stable angina with hyperlipidemia

Dosage

Maximum dose of amlodipine inthe combination is 10mg/day and for atorvastatin is 80mg/day

Take with or without food

Pharmacology

Amlodopine inhibits the transmembrane influx of calcium into vascular smooth muscle and cardiac muscle. The drug binds to dihydropyridine and nondihydropyridine binding sites. It is a peripheral arterial vasodilator that acts directly on vascular resistence and reduction in blood pressure.

Atorvastain lowers plasma cholestrereol and isoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and by increasing the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL

. Amlodopine and Atorvastin have been proved to be effective inhypertension and angina, and dyslipidemia respy.

Pharmacokinetics

The rate and extent of absorption of amlodopine and atorvastain from the combination product was similar to the individual drugs.

Rationale for the combination-

Study has revealed that amlodopine and atorvastatin combination is clinically efficacious in controlling BP and correcting hypererliperdimia.

Take with or without food