Mycocardial infarction

Transcient ischemic attacks

Peripheal arterial disease

Diabetes mellitus

Smoking, obesity

Indication-

Mycocardial infarction

Transcient ischemic attacks

Peripheal arterial disease

Diabetes mellitus Smoking, obesity

Dosage-

1 tab daily

Pharmacology

Atorvastain lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver.It also increases the number of LDL receptors on the cell surface to enhance uptake and catabolism of LDL Hyperthomocytenemia as a clinical finding may result from pyridoxine, cobalamin or folate deficiency and may also be due to inherited or acquired defects in the homocysteine metabolism.

Rationale for the combination-

Various clinical trials have demonstrated the efficay of atorvastain and a combination of methylcobalamin, folate,Vitamin B6, in normalizing theliupid and homocysteine levels, and thus reducing cardiovascular mortality and morbidity.

The unique drug combination by keeping check over both lipids and homocysteine levels, is useful in patients with atherosclerosis or at risk of artherosclerosis.