Sulbactam+ Cefotaxime - Anti-Infectives- (FDC- List)- (Apr 2000)
Drug Name:
Sulbactam+ Cefotaxime - Anti-Infectives- (FDC- List)- (Apr 2000)
List Of Brands:
Indication Type Description:
Pharmacology/ Pharmacokinetics
Drug Interaction:
Concomitant admin of cephalosporin and aminioglycoside antibiotics
Indication:
Genito-urinary infection
Lower respiratory tract infection
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
1.Sulbactum sodium eq.to 04-04-2000
Sulbatum 1000mg +
Cefoperazone sodium eq. to
Cefoperazone 1000mg each vial injection
IV/IM injection
Addl.stgth
2.Sulbactum sodium eq.to 16-03-2000
Sulbactum 500mg +
Cefoperazone sodium eq. to
Cefoperazone 500mg each vial injection
IV/IM ijection
For the treatment of RTI, UTI, (lower and upper),
septicemia, Meningitis, Skin & Soft tissue infection,
Endometritis, other infection of genitl tract, intra -
abdominal infection bone & joint infection
Adverse Reaction:
Local reactions inculding pain at the injection site and phloebitis
Others - skin rash, diarhoea, nausea and vomiting, colitis
Contra-Indications:
Hypersensitivity to cefotaxime
Special precations-
Previous hypersensitivity to penicillns or other drugs
Patients with renal insufficency
History of GI disease , esp colitis
Dosages/ Overdosage Etc:
Indication-
Genito-urinary tract infection
Lower respiratory tract infection
Dosage-
Mild to moderate infection- 1/0.5 g to 2/1 g of cefotaxime /sulbactum every 8-12 hours
Moderate to severe infections-
1/0.5g to 2/1 g of cefotaximine/sulbactum every 6-8 hours
Child- 100/50 mg to 150/75mg of cefotaxime/sulbactum kg/day in 3 divided doses
Life threatening infection- dose of cefotaxime may be increased up to 12g/day
Max dose - sulbactum
Adult- 4g
Child 80mg/.kg in divided doses
Pharmacology/ Pharmacokinetics:
Pharmacology
The anti bacterial component of cefotaxine /sulbactum is cefotaxime, a third genneration antibiotic. Cefotaxime is a bacterial drug which inhibits the bacterial wall synthesis of the active;y dividing cells by binding to one or more penicillin binding proteins
Pharmacokinetics
Pharmacokinetics of cefotaxime and sulbactum have been reported to be unchanged and similar when administered alone or in combination.
