Concomitant admin of cephalosporin and aminioglycoside antibiotics

Genito-urinary infection

Lower respiratory tract infection

Local reactions inculding pain at the injection site and phloebitis

Others - skin rash, diarhoea, nausea and vomiting, colitis

Hypersensitivity to cefotaxime

Special precations-

Previous hypersensitivity to penicillns or other drugs

Patients with renal insufficency

History of GI disease , esp colitis

Indication-

Genito-urinary tract infection
Lower respiratory tract infection

Dosage-

Mild to moderate infection- 1/0.5 g to 2/1 g of cefotaxime /sulbactum  every 8-12 hours

Moderate to severe infections-
1/0.5g to 2/1 g of cefotaximine/sulbactum every 6-8 hours

Child-  100/50 mg to 150/75mg of cefotaxime/sulbactum kg/day in 3 divided doses

Life threatening infection- dose of cefotaxime may be increased up to 12g/day
Max dose - sulbactum
Adult- 4g
Child 80mg/.kg in divided doses

Pharmacology

The anti bacterial component of cefotaxine /sulbactum is cefotaxime, a third genneration antibiotic. Cefotaxime is a bacterial drug which inhibits the bacterial wall synthesis of the active;y dividing cells by binding to one or more penicillin binding proteins

Pharmacokinetics

Pharmacokinetics of cefotaxime and sulbactum have been reported to be unchanged and similar when administered alone or in combination.