Oral anticoagulants, digitalis Hypoglycaemics , oral contraceptives (reduced efficacy ) Disulphram -avoid, phenytoin, corticosteroids, cyclosporin, Dapsone, quinidine, nacrcotics Alcohol - risk of hepatitis Pyridoxine defeciency Increased risk of neuropathy

Tuberculosis in children

GI disturbances, hepatic disorders, Hepatitis, jaundice Leucopenia, eosinophillia Flu-like syndrome. Hypoglycaemia Headache, drowsiness, dizziness Visual disturbances Dose dedpendent peropheral neuropathy

Jaundice, optic neuritis, concurrent admin. of ritonovir /squinavir,atezanavir

Special precautions-

Test visual functions before and during therapy Iimpaired liver function, Increased liver danage with increasing age Very youmg or malnourished patients

Elderly Perform blood counts, renal and liver function tests regularly Diabetes Pregnancy Lactation

Tuberculosis in children

Dosage-

Children - 2-3 caps depending on weight daily as a single dose either 1 hour before or 2 hours after meals

Use contraindicated during pregnancy and lactation Observe caution if required to be used