Oral anticoagulants, digitalis Hypoglycaemics , oral contraceptives (reduced efficacy )

Disulphram -avoid, phenytoin, corticosteroids, cyclosporin, Dapsone, quinidine, nacrcotics

Alcohol - risk of hepatitis

Pyridoxine defeciency Increased risk of neuropathy

Short course and retreatment of tuberculosis in children

GI disturbances, hepatic disorders, Hepatitis, jaundice Leucopenia, eosinophillia Flu-like syndrome. Hypoglycaemia Headache, drowsiness, dizziness Visual disturbances Dose dedpendent peropheral neuropathy

Jaundice, optic neuritis, concurrent admin. of ritonovir /squinavir,atezanavir

Special precautions-

Test visual functions before and during therapy Iimpaired liver function, Increased liver danage with increasing age Very youmg or malnourished patients

Elderly Perform blood counts, renal and liver function tests regularly Diabetes Pregnancy Lactation

Short course and retreatment of tuberculosis in children

Dosage-

Children - 2-3 caps dailty depending on weight to be given as a single dose either 1 hour before or 2 hurs after meals

Use contraindicated during pregnancy and lactation Observe caution if required to be used