Treatment of mild to modate ulcerative colitis and maintenance of remission

Diarrhea, nausea, vomiting, abdominal pain, exacerbation of symptoms of colitis Headache, hypsersensitivity reactions (including rash and urticaria)

Rarely- acute pancreastitis, heaptistis, myocarditis, pericarditis, Lung disorders, including eosinophillia andfibrosing alveolitis)

Peripheral neuropathy, blood disoreders( including agarnulocytosis, aplastic anemia, leucopenia, methaemoglobinemia, neutropenia, and thrombocytopenia

Renal dyfunction(intestinal nephritis, nephrottic lupus erythematosus-like syndrome. Steven-Johnson syndrome,alopecia

Amonisalicylates should be avoided in salicylate hypersensitivity

Special Precautions-

Used with caution inrenal impairment ,during pregnancy,breast-feeding blood disorders can occur

Indication-

Treatment of mild to modate ulcerative colitis and maintenance of remission

Dosage-

2.25g 3 times daily, until remission occurs or up to max 12 weeks

Maintenance- 1.5g twice daily adjustedacording to response- max 6g daily

Instruct patients not to take balsalzide if they have a hypersensitivity to salicylates eg. Aspirin

Consult doctor if they experience a worsening of ulcerative colotis, if they are diagnosied with pyloric stenosis as balsazide capsules may be slow to pass through their digestive tract.

Pharmacology-

Mechnasm of action of 5ASSA is unknown,but it appears to be topical rather than systemic. It diminishes inflammation by blocking mucosal productin of arachiodic acid metabiolites in the colon which is produced by nboth the cyclogenase pathways i.e. prostanoids and the lipoxygenase pathways i.e leukotrienes and hydroxyeicostatetraenoic acids is increased in pts with chronic inflammatory bowel disease

Pharmacokinetics-

The absorption of intact balasazide is very low and variable. The mean Cmax occurs approx 1-2 hrs after single oral doses of 1.5 g or 2.25 g. It shows plasma proteins binding of > 99% . It undergoes azoreduction to give 5-aminosalicylic acid and 4-aminobenzoyl-(beta)-alanine and their N-acretylylateded metabolites which are present in plasma, urine and faeces.

Take with or immediately after meals

Use with caution during pregnancy and breast feeding