NSAIDs include-

Propionic acid- Fenoprofen, Flurbiprofen, Ibuprofen, Ketoprofen, Naproxen, Naproxen Sodium, Oxaprozin Acetic acids- Diclofenac sodium, Etodolac, Indomethicin, Ketorolac, Nabumetone, Sulindac, Tolmetin Fenamates (anthralic acids) - Meclofenamate, Mefenamic acxid Oxicams- Piroxicam

Refer- Ibuprofen 

Potentiates methorexate, lithium, protein bound drugs Increased risk of GI Bleed with aspirin, corticosteroids, smoking, anticoagulants May antagonise or increase risk of renal failure with ACE inhibitors, diuretics Monitor oral anticoagulants, antihypertensives

LIST OF DRUGS DURING 2007

New Drugs Approved by (DCI) Drug Controller  GENERAL -  India  For Marketing                                                                                   (Ref- IDMA Publication)

Rheumatoid arthiritis Osteoarthiritis 

NSAIDs include-

Propionic acid- Fenoprofen, Flurbiprofen, Ibuprofen, Ketoprofen, Naproxen, Naproxen Sodium, Oxaprozin Acetic acids- Diclofenac sodium, Etodolac, Indomethicin, Ketorolac, Nabumetone, Sulindac, Tolmetin Fenamates (anthralic acids) - Meclofenamate, Mefenamic acxid Oxicams-

GI upset, CNS effects, tinnitus, blurrred vision, Dysuria, oedema, GI ulcer bleed, photosensitivity Blood dyscrasias, Renal or hepatic dysfunction Rash ( discontinue if occurs ) Risk of cardiovascular events

Aspirin allergy Coronary artery bypass graft surgery Advanced renal disease Third trimester of pregnancy Lactation

Special Precaution-

Renal or hepatic dysfunction Discontinue if renal or hepatic disease develops History of GI bleed/ulcer Bleeding disorders Monitor CBC, hepatic and renal function in chronic use and for GI bleed ulcer Heart failure Asthma Hypertension Alcoholism Elderly, debilitated, dehydrated Pregnancy Labour

Rheumatoid arthiritis Osteoarthiritis Rheumatoid arthiritis

Dosage-

- 1.2g once daily Max. 1.8g or 26mg/kg daily, whichever is less, in divided doses Lower body weight, milder disease or on dialysis-initially 600mg once daily, max 1.2g daily

NSAIDs include-

Propionic acid- Fenoprofen, Flurbiprofen, Ibuprofen, Ketoprofen, Naproxen, Naproxen Sodium, Oxaprozin Acetic acids- Diclofenac sodium, Etodolac, Indomethicin, Ketorolac, Nabumetone, Sulindac, Tolmetin Fenamates (anthralic acids) - Meclofenamate, Mefenamic acxid Oxicams- Piroxicam Refer- Ibuprofen

Contraindicated for use during pregnancy and lactation.

Observe caution if required to be used