Drug Information

Updated On: 27-02-2024

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Methimazole- @ - Antithyroid Drugs

Drug Name:
Methimazole- @ - Antithyroid Drugs

List Of Brands:

METHIMEZ

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Drug Interaction:

clozapine, steroids digitalis. potentiates anticoagulants

Indication:

Hyperthyroidism

Adverse Reaction:

rash, g i disturbances,arthalgia parraesthesia hair and taste loss agranulocytosis blood dyscrasias anemia hepatic dysfuntion

Contra-Indications:

pregnancy lactation special precautions- discontinue if agranulocytosis , aplastic anemia, exfoliative dermatitis , hepatitis, or elevated transaminase > 3 times the normal values occurs monitor prothrombin time, WBC, bone marrow function

Dosages/ Overdosage Etc:

Hyperthyroidism

Dosage-

Initially 15-60mg daily in 3 divided doses dependening on the severity of disease

Maintenance- 5-15mg daily

Chidren- initially 0.4mg/kg daily in 3 divided doses

Maintenance- half the initial dose

Patient Information:

Ref- Advice for the Patient - Drug Information in Lay Language- USPDI (1997)

Antithyroid Drugs include-

Methimazole , Propylthiouracil

1.Allergies-

Tell your doctor if you have ever had any unusual or allergic reaction to methimazole

or propylthiouracil. Also tell your healthcare provider if you are allergic to any other

substances, such as foods, preservatives or dyes.

2.Pregnancy-

Use of too large a dose during pregnancy may cause problems in the fetus. However,

use of the proper dose , with careful monitoring by the doctor, is not likely to cause

problems

3. Breast-feeding-

These medicines pass into breast milk.(Methimazole passes into breast milk more

freely and in higher amounts than propylthiouracil). However , your doctor may allow

you continue to breast feed . If you are taking a large dose, it may be necessary for

you to stop breast-feeding during treatment

4.Children-

This medicine has not been used in children and in effective doses. has not shown

to cause different side side effects or problems in children than in adults.

5.Teen agers-

The medicine has not been used in teenagers and in effective doses, has not shown

to cause different side effects or problems in teenagers than it does in adults.

6.Older adults-

Elderly people may have an increased chance of certain side effects during

treatment. Your doctor may need to take certain precautions while you are

taking this medicine

7.Other medicines-

Although certain medicines should not be used together at all, in other cases two

different medicines may be used together even interaction might occur. In such

cases your doctor may want to change the dose , or other precautions may be

necessary.

When you are taking antithyroid drugs , it is especially important that

your doctor know if you are taking any of the following-.

Amiodarone or

Iodinated glycerol or

Potassium Iodide (eg.Pima) - the use of these medicines may change the

effect of antithyroid drugs

Anticoagulants(blood thinners) the use of antithyroid drugs may affect the

way the anicoagulants work on your body.

Digitalis glycosides- the use antithyroid agents may affect the amount of

digitalis glycosides in the blood stream

8.Other medical problems-

The presence of other medical problems may affect the use of antithyroid agents.

Make sure you tell your doctor if you have other any other medical problems,

Liver disease- the body may get this medicine out of thre bloodstream at the usual

rate, which may increase the chance of side effects.

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Disclaimer: Every effort has been made to ensure that the information provided in this Database is authentic and accurate. Commissions or omissions in the database, if any, are purely inadvertent and the site owner shall not accept any liability whatsoever for any adverse consequences of any nature arising to any individual or third party, as a result of usage of this information.