Amantadine, ketamine, dextromethrophan, triamterene, levodopa, dopaminergic agonists, anticholinergics, barbiturates neuroleptics, baclofen, dantrolene, cimetidine, ranitidine, procainamide , quinidine, quinine, nicotine, warfarin, hydrochlorthiazide, phenytoin

Mild to severe Alzheimers dementia

Dizziness, headache, tiredness, hypertension, Constipation, pain, GI upset, agitation, sleep disturbances, Hallucinations, Cough, UTI, urinary incontinence, Breathlessness Ocular toxicity

Severe hepatic impairment Lactation Severe renal impairment Seizures or history of convulsions

Special precautions-

Moderate renal impairment, Recent MI , Uncompensated heart failure, Uncontrolled hypertension, Pregnancy Alkaline urine, Hepatic impairment

Mild to severe Alzheimers dementia

Dosage-

Initially 5mg daily during 1st week increasing at weekly intervals in increments of 5mg daily to maintenance of 20mg daily by 4th week.

Severe renal impairment - Max 5mg twice daily

Contraindicated for use during pregnancy and lactation. Observe caution if required to be administered