Phenyramidol increase plasma concentrations of diphenyhydantoin when administered together in elpileptic patients Also known to inhibit themetabolism of tolbutamide and betahydroxycoumarin

Lumbago Integumental Pain Muscle stiffness

In sensitive patients phenpyramidol may give rise to gastric irritation or cause nausea and vimmitting when taken on an empty stomach Therefore advisable to give phenyramidol with or after meals.

Allergic reactions observed in rare instances. As a statutory precaution, it is advisable that phenpyramidol should be avoide during pregnancy and lactation

Lumbago Integumental Pain Muscle stiffness

Dosage-

Recommended oral dosage- 400mg t.d.s to q.d.s for 3 to 7 more days. depending on the severity of pain/accompanying muscul-skeletal discomfort

PHARMACODYNAMICS-

Phenyramidol hdrochloride interrupts inter-neuronal and polysynaptic refluxes in the spinal cord and brain stem,. thereby exerts -dual- action namely skeletal muscle relaxation and analgesia

PHARMACOKINETICS- 

After oral administration, the drug is readily absorbed from the GI tract. Peak plasma concentration is acheived in 45 minutes. The elimination half-life is found to be approximately 10 hours. Considerable amount is principaly excreted as pynyramidol glucorinide into urine. Small proportions aee also excreted in the feces

Advisable to give phenyramidol with or after meals.

It is advisable that phenpyramidol should be avoided during pregnancy and lactation