Inducers or inhibitors of CYP3A4 may alter solifenacin pharmacokinetics

Recommended not to exceed 5mg daily dose when administered with therapeutic dose of ketoconazole or ther CYP4A4 inhibitors

ADVERSE REACTIONS-                                     

CNS -               Dizziness  2%                

GI -      Abdoninal pain  1  %  Constipation 3  %      Dry mouth   4  %      
             Dyspepsia  1 %       Nausea   2   %  Vomiting  1 %     
                           
 GU     Urinary retention  1%   Urinary tract infn  3 %   Psychiatric depn  1%                    
                              
 RESPIRATORY -     Cough      rare                               

              
 SPECIAL SENSES -  Dry eyes 1%   Vision blurred 2%
                         
                              

Urinary or gastric retention,
Uncontrolled narrow-angle glaucoma in patients who are at risk these conditions

Special precautions-
 Bladder outflow obstruction- caution patients with clinically significant bladder outflow obstruction

GI obstructive disorders and decreased GI motility - administer  with caution to patients with GI obstructive disorders because of risk of gastric retention

Controlled narrow angle glaucoma -  use with caution.Solifenacin is contraindicated for use in  these conditions

Patients with congenital or acquired QT prolongation-  solifenacin is known to prolong QT interval. Observe caution.
 
Renal function impairment- use with caution

Hepatic function impairment-  observe cautioni

Pregnancy-
Administer during pregnancy only if the benefit to the mother outweighs the potential risk to the fetus.

Lactation-
Use caution before administering to breast feeding women

Children-
Safety and efficacy  not established in children

Indications-

Treatment of overactive bladder with symptoms of urinary incontinence , urgency and frequency

Dosage-

5mg once daily is well tolerated. Dose may be increased to 10mg once daily

Take with liquids .

Administer with or without food

Contact physician if you experience sever abdominal pain, or become constipated for 3 or days.

Can cause blurred vision. Observe caution before undertaking hazardous tasks.

Heat prostration ( caused by decreased sweating ) can occur , especially when used in hot weather. Observe caution

Administer with or without food

Pregnancy-

Administer during pregnancy only if the benefit to the mother outweighs the potential risk to the fetus.

Lactation-

Use caution before administering to breast feeding women

Children-

Safety and efficacy not established in children