See contraindications- Rifabutin, Lopinavir, Retronavir, Saquinavir, Indinavir, Atazanavir, Efavirinz, Didasonine Trazodone, Despramine, Antihistamines Neuroliptics,Sedatives Digoxin

Clarithromycin Risperidone,Thioridazine Warfarin Phenobarbital Phenytoin, Carbamazioine Azole antifungals Calcium antagonists, beta blockers Immunosuppressants Buprenorphine,

methadone Sidenafil, tadalafil Sertraline, paroxtine Ethyl osetradiol, norethindrone, steroids

Severe rash discontinue if it develops

GI upset, anorexia Headache, dizziness, asthenia, fatigue, prurituis, insomnia

Peripheral neuropathy, Hyperglycemia Hyperlipidaemia and other metabolic abnormalites

Lipodystrophy Increased CPK, pancreatic enzymes Arthalgia, osteoporosis, musculoskeletal and joint stiffness,myalgia

Hepatitis, Myosistis Drug- induced hepatitis

Rarely rhabomyolysis

Severe hepatic impairment Concomitant rifampicin, Alfuzosin St.johns wart, ergot derivatives Cisapride, statins, Pimozide, Midazolam,Triazolam Antiarrhythmics Lactation

Special precautions-

Mild to moderate hepatic impairment, severe renal impairment Sulfonamide allergy/chronic hepatitis B or C haemophilia,

Diabetes Fat redistribution Risk of immune reactivation syndrome in patients with severe immune deficiency within first few weeks or months of starting combination of antiretroviral theapy

Risk of osteonecrosis Monitor for liver enzymes, signs of joint pain or immobility

Elderly, Pregnancy

For the treatment of Human Immnological deficiency (HIV) infection in                          antiretrovir to more than one protease  inhibitor when co-administered                             with 100mg Ritonavir and other antiretroviral  agents. 

Anti-retroviral -

Dosage-

experienced patients- 600mg twice daily with retronavir 100mg twice daily

Children - under 6 years and <20kg not recommended

Anti-retroviral experienced children- 20-29 kg - 375mg twice daily with retronvir, 50mg twice daily

30-39kg - 450mg twice daily with retronavir,

60mg twice daily > 40kg - 600mg twice daily with retronavir, 100mg twice daily

All to be taken with food with other antiretrovirals

To be taken with food with other antiretrovirals

Pregnancy and Lactation- Use Contraindicated