Diclofenac interacts with anticoagulants, Cyclosporin, Trianterene, Sucralfate Colestyramine, Colestipol, Corticosteroids Increases blood levels of Digoxin, Lithium, Methotrexate Rabeprazole is known to interact with Ketoconazole, Itraconazole, Diazepam, Phenytoin, Warfarin

Osteoarthiritis Rheumatoid Arthiritis Inflammatory conditions Primary Dysmenorrhea Post Surgical Pain

Diclofenac Causes Abdominal Burning, pain, cramping, nausea, liver toxicity, rash, kidney impairment Ringing in the ears, lightheadedness Rabeprazole is associated with Diarrhea, Nausea, Abdominal pain, Asthenia, Flatulence, Pharyngitis, Vomiting, No-specific back pain, Dizziness, Constipation and insomnia

Hypersensitivity, History of Allergic reactions ( bronchospasm, shock, rhinitis, urticaria ) Third Trimerster pregnancy, Lactation, Herat, Liver and renal insufficiency

Osteoarthiritis Rheumatoid Arthiritis Inflammatory conditions Primary Dysmenorrhea Post Surgical Pain Diclofenac Potassium 100mg + Rabeprazole Sodium 50mg sustained release capsule once a day

Pharmacokinetics

Absorption of Diclefenac is 100% by oral administration compared to intravenous route It is found to be protein bound. Peak Plasma concentration ranges from 1.4 to 3.0 mcg/ml with half life of 1.8 hrs in plasma. due to firts pass bioavailability is linited to 50-60% Elimination takes place thriugh urinary and billiary excretion as glucuronide and sulfate conjugates.

Rabeprazole is acid labile and absorption takes place in stomach. It attaind t max in 3.5hrs. Food does not alter tmax but it delays the time to tmax buy about 1.5hrs It is 95-98% plasma bound with bio-availability of 52%. Rationale for Combination- Diclofenac is preferably prescribed along with rabeprazole. While Dicoofenac actsto relieve pain and infalmmattion, Rabeprazole is an ideal combination for chronic pain and inflammation in patients with predisposed to gastrointestinal intolerance.

Rabeprazole- Food does not alter t max but it delays the time to t max buy about 1.5hrs

Contraindicated during Third Trimerster pregnancy, Lactation,