Concomittant use with other anticholinergics that produce constipation, dry mouth, - severity increased

Drugs eliminated  by tubular secretion eg digoxin, procainamide, pancruronium, morphine, vancomycin. may increase serum concentration of trospium

Treatment of overactive bladder with symptoms of urinary incontinence , urgency and frequency

                  
ADVERSE REACTIONS-                                         
 
CNS      Headache  4.
 
GI       Abdominal pain 2 %  Constipation  10% Dry mouth 20 %
            Dyspepsia   1%  Flatulance  1%
          
 GU     Urinary retention 1%        
         

OPHTHALMIC -  Dry eyes  1 %
         
MISCELLANEOUS -  Fatigue 2 %
         

Urinary or gastric retention, Uncontrolled narrow-angle glaucoma in patients who are at risk these conditions

Special precautions-

Controlled narrow angle glaucoma- use with caution on patients being treated

Decreased GI motility - administer with caution to patients with GI obstructive disorders because of risk of gastric retention

Hepatic function impairment- observe caution

Renal function impairment - Observe caution

Pregnancy- Administer during pregnancy only if the benefit to the mother outweighs the potential risk to the fetus.

Lactation- Use caution before administering to breast feeding women

Children- Safety and efficacy not established in children

Indications

Treatment of overactive bladder with symptoms of urinary incontinence , urgency and frequency

Dosage-

20mg twice daily . Trospium should be dosed at least 1 hour before meals or given on an empty stomach

Heat prostration ( caused by decreased sweating ) can occur , especially when used in hot weather. Observe caution

Can cause blurred vision, diziness. Observe caution before undertaking hazardous tasks.

Inform patients that alcohol may enhance the drowsiness caused by anticholinergics agents

Trospium should be dosed at least 1 hour before meals or given on an empty stomach

Pregnancy-

Administer during pregnancy only if the benefit to the mother outweighs the potential risk to the fetus.

Lactation-

Use caution before administering to breast feeding women

Children-

Safety and efficacy not established in children