Antiadrenergic agents ( Peripherally acting )include- Reserpine, Guanithidine monosulphate, Guandrel sulfate, ( Alpha-1- blockers), Prazosin,Terazosin, Doxazosin, Tamsulosin, Silodosin, Alfuzosin Hcl

Refer - Prazosin

Benign Prostatic Hyperplasia 

Antiadrenergic agents ( Peripherally acting )include- Reserpine, Guanithidine monosulphate, Guandrel sulfate, ( Alpha-1- blockers), Prazosin,Terazosin, Doxazosin, Tamsulosin, Silodosin, Alfuzosin Hcl

Refer - Prazosin

Renal function impairment- Silodosin is contraindicated in patients with severe renal impairment ( creatinine clearance CrCl less than 30mL/min)

In patients with moderate renal impairment CrCl 30 to 50mL/min the dosage should be reduced to 4mg once daily taken with a meal.

No dosage adjustment is required in patients with renal impairment CrCl 50 to 80mL/min

Hepatic function impairment - silodosin has not been studied in patients with severe hepatic impairment ( Child Pugh score of 10 or greater and therefore contraindicated No dosage adjustment is needed in patients with mild modera hepatic impairment.

Benign Prostatic Hyperplasia

Dosage-

8mg orally once daily with meals

Renal function impairment- Silodosin is contraindicated in patients with severe renal impairment ( creatinine clearance CrCl less than 30mL/min) In patients with moderate renal impairment CrCl 30 to 50mL/min the dosage should be reduced to 4mg once daily taken with a meal.

No dosage adjustment is required in patients with renal impairment CrCl 50 to 80mL/min

Hepatic function impairment - silodosin has not been studied in patients with severe hepatic impairment ( Child Pugh score of 10 or greater and therefore contraindicated

No dosage adjustment is needed in patients with mild modera hepatic impairment.

Reserpine, Guanithidine monosulphate, Guandrel sulfate, ( Alpha-1- blockers), Prazosin,Terazosin, Doxazosin, Tamsulosin, Silodosin, Alfuzosin Hcl

Refer - Prazosin

Antiadrenergic agents ( Peripherally acting )include- Reserpine, Guanithidine monosulphate, Guandrel s

Refer - Prazosin

Can be taken with meals