Alfuzosin Hcl is quinazoline derivative. Alfuzosin relaxes tone of the prostrate smooth muscle, prostrate capsule, bladder neck, and proximal urethra. It competitively and selectively binds to the postsynaptic alpha1 -adrenergic receptors in the lower urinary tract. Alfuzosin also relaxes sympathetic nervous stilmulation, reduces resting urethral pressure and inhibits urethral hypertonia-induced sympathetic nervous stimulation.
Extended release alfuzosin is absorbed slowly with a mean maximum plasma concentration Cmax of 18.6mcg/lit at approx nine hours. Because the extent of absorption is decreased by 50% in fasting conditions, extended release alfusozin shoud be taken immediately after a meal.
The agents bioavailability is 49% and the mean area under the mean area-under-the plasma concentration curve over 24 hrs (AUC24) is 238mcg hour/liter.Extended release alfuzosin undergoes extensive hepatic metabolism that promptly involves cytochrome P450 isoenzyme CYP3A4
Interaction with Food:
Extended release alfusozin shoud be taken immediately after a meal.Swallow whole. Do not chew or crush
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