Antiadrenergic agents ( Peripherally acting )include-

Reserpine, Guanithidine monosulphate, Guandrel sulfate, ( Alpha-1- blockers), Prazosin,Terazosin, Doxazosin, Tamsulosin, Silodosin, Alfuzosin Hcl

Refer - Prazosin 

 Concurrent use of potent CYP3A4 inhibitors( ie. ketoconazole, itraconazole, and ritonovir) can result in prolonged alfuzosin exposure and is therefore contraindicated

With the coadmin of atenolol, the Cmax and AUC of alfozosin increased by 28% and 21% respy

With dilitiazem the Cmax and AUC of alfuzosin are elevated 1.5 fold and 1.3 fold respy

Precautions should be taken when administred along with drugs that cause changes in QT interval

Both tadalafil and vardenafil are contraindicated for use with alfuzosin

Benign prostatic hyperplasia

Antiadrenergic agents ( Peripherally acting )include-

Reserpine, Guanithidine monosulphate, Guandrel sulfate, ( Alpha-1- blockers), Prazosin,Terazosin, Doxazosin, Tamsulosin, Silodosin, Alfuzosin Hcl

Refer - Prazosin 

LIST OF DRUGS DURING 2004

LIST OF DRUGS DURING 2007

Approved by (DCI) Drug Controller  GENERAL -  India  For Marketing                                                                                   ( Ref- IDMA Publication) 

Alfozosin was well tolerated in clinical trials.

The most commonly reported vasodilator side effects include

orthoststic hypotension, headache, dizziness, and tachycardia

Renal function impairment-

Systemic exposre was increased by approximately 50% in pharmacokinetic studies of patients with mild, moderate, severe heptic insufficiency.

Caution should be excercised when Alfuzosin is administered to patients with severe renal insufficiency

Hepatic function impairment-

Alfuzosin should not be given to patients with moderate to severe hepatic insufficiency.

The pharmcokinetics of alfuzosin have not been studied in patients with mild hepatic insufficiency

Indication

Benign prostatic hyperplasia

Dosage

Adults- recommended dose is 10mg daily to be taken immediately after the same meal each day

 Elderly - no overall differences in safety or effectiveness were observed between elderly and younger subjects

Antiadrenergic agents ( Peripherally acting )include-

Reserpine, Guanithidine monosulphate, Guandrel sulfate, ( Alpha-1- blockers), Prazosin,Terazosin, Doxazosin, Tamsulosin, Silodosin, Alfuzosin Hcl

Refer - Prazosin

Extended release - take immediately after the same meal each day. Swallow whole. Do not chew or crush 

Antiadrenergic agents ( Peripherally acting )include-

Reserpine, Guanithidine monosulphate, Guandrel sulfate, ( Alpha-1- blockers), Prazosin,Terazosin, Doxazosin, Tamsulosin, Silodosin, Alfuzosin Hcl

Refer - Prazosin

Pharmcology

Alfuzosin Hcl is quinazoline derivative. Alfuzosin relaxes tone of the prostrate smooth muscle, prostrate capsule, bladder neck, and proximal urethra. It competitively and selectively binds to the postsynaptic alpha1 -adrenergic receptors in the lower urinary tract. Alfuzosin also relaxes sympathetic nervous stilmulation, reduces resting urethral pressure and inhibits urethral hypertonia-induced sympathetic nervous stimulation.

Pharmacokinetics

Extended release alfuzosin is absorbed slowly with a mean maximum plasma concentration Cmax of 18.6mcg/lit at approx nine hours. Because the extent of absorption is decreased by 50% in fasting conditions, extended release alfusozin shoud be taken immediately after a meal.

The agents bioavailability is 49% and the mean area under the mean area-under-the plasma concentration curve over 24 hrs (AUC24) is 238mcg hour/liter.Extended release alfuzosin undergoes extensive hepatic metabolism that promptly involves cytochrome P450 isoenzyme CYP3A4

Extended release alfusozin shoud be taken immediately after a meal.Swallow whole. Do not chew or crush