Reports not available

Rheumatoid Arthiritis

Adverse reactions reported to have occurre in < 5% of patients treated for RA 

Injection site reaction  70%

Worsening of RA     16%

Upper respiratory ttract infection 12%

Headache 10%

Nausea 8%

Sinusitis  7%

Diarrhea 7%

Arthalgia 6%

Flu like symptoms 5%

Abdominal pain 5%

Known hypersensitivity to E.Coli -derived proteins, anakinra or any component

Warnings-

Infections- associated with an inceased incidence of serious infections . discontinue administration if patient develops serious infection. Do not initiate treatment in patients with active infection

Vaccinations- do not give live vaccines concurrently with anakinra

Hypersensitivity - hypersensitivity reactions with anakirna are rare.If severe hypersensitivity reactions develops, discontinue administration andinitiate appropriate therapy

Renal funtion impairment- the drug is exrcreted by  the kidney , the risk of toxic reaction is greater in patients with impaired renal function

Pregnancy- no adequate and well controlled studies in pregnant women. Use during pregnancy only if clearly needed

Lactation- excercise caition if anakinra  is administered to nursing mothers

Children- safety and efficacy not established in children

Elderly- use caution while administering to elderly patients

Indication-

Rheumatoid arthiritis

Dosage-

Recommended dose is 100mg/day administered daily by SC injection. Administer the dose at approximately at the same time every day

1. Inform your doctor if signs or symtoms of  adverse reactions occur.

2. Patients should be cautioned against the reuse of needles or syringes

Pharmacolgy-

Anakinra is a recombinant , nonglycosylated form of human interluin-1 receptor antagonist

It acts by blocking the biologic activity of IL -1 by competively inhibiting IL -1 binding to the interleukin -1 type receptor IL- IRI .

Pregnancy-

No adequate and well controlled studies in pregnant women. Use during pregnancy only if clearly needed

Lactation-

Excercise caition if anakinra  is administered to nursing mothers

Children-

Safety and efficacy not established in children

Elderly-

Use caution while administering to elderly patients