Ciclosporin, tacrolimus , rifampicin, efavirenz, nevirapine, dexamethasone, phenytoin,
carbamazepine, Glucose incompatibility

Treatment of invasive candidiasis

Inj site reaction, headache, dyspnoea, angioedema,
brochospasm, GI upset, rash, fever,

pruritus, chills, arthralgia, hypertension, tachycardia,

raised liver enzyme, decreased haemotocrit,
hypokalaemia, hypoalbuminaemia

Children- also hypotension

Hepatic impairment in children
severe hepatic impairment in adults

Lactation

Special Precaution-
Moderate hepaticimpairment in adults.
Monitor liver function tests

Pregnancy

Indication

Treatment of invasive candidiasis

Dosage-
Adults- reconstitute and dilute soln before administration by slow i,v. ing over 1 hour

Under 80kg-  initially 70mg on Day 1  then 50mg daily

Over 80kg - 70mg daily
Continue treatment for 14 days after last positive culture and of invasive aspergillosis for 7 days
after resolution of symptoms

Empirical therapy should continue up to 72 hours after resolution of neutropenia
If fungal infection is confirmed treat for a min period of 14 days and for at least 7 days after both neutropenia and clinical symptoms resolve

Children -reconsittute and dilute soln. before administering by slow i.v. inf over 1 hour

Under 3 mths not recommended

3 months - 70mg/m2 on Day 1  then 50mg/m2  daily if required Max 70mg/m2 daily

Duration of treatment as adults

Use contraindicated. Observe caution if required to be administered.