Drug interaction-

Vertoporin photodynamic therapy ( PDT ) -
 ranibizumab intravitreal injectiion has been used  adjunctively with verteporfin PDT

Macular degeration

Severe adverse reactions related to the injection  have occured in less than 0.1% intravitreal
injections, including endophthalmitis, iatrogenic traumatic cataracts, and rhegmatogenous
retinal detachments

Ocular or periocular infections known hypersenstivity to  ranibizab  or any of its
components

Special Precautions /Warnings-

Endophthalmitis and retinal detachments-
Intravitreal injections, including those with rhambizumab  have been associated with
endophthalimitis and retinal detachments. Use proper asceptic techniques when
administering ranizumab. Monitor patients following injection to permit  early  treatment
of any injection.

Increased intraocular pressure-
Increase in intraocular pressure have been noted within 60 minutes of intraocular 
injection with ranizumab. Monitor and manage intraocular pressure

Pregnancy - give ranizumab to a pregnant woman only if clearly required

Lactation- excercise caution when ranizumab is administered to breast feeding woman

Children- safety and efficacy of ranizumab in children have not established

Indication-

Macular degeration

Dosage-

Adminster 0.5mg ( 0.05ml ) by intravitreal injection once a month.

Although less effective, treatment may be reduced to 1 injection every 3 months after
the first 4 injections , if monthly injection is not feasible

Storage - refrigerate at 2 to 8C ( 36 to 46F ). Do not freeze. Do not use beyond the date
stamped on the label. store original carton until time for use 

1. Advice patient that they are at risk of developing endophthalmtis in the days folowing
   ranizumab administration

2. If the eye becomes red , sensitive to light, painful or develops a change in vision advice
 the patient to seek immediate care from  an ophthalmologist.

Pregnancy -
Give ranizumab to a pregnant woman only if clearly required

Lactation-
Excercise caution when ranizumab is administered to breast feeding woman

Children-
Safety and efficacy of ranizumab in children have not established