Hyperuricemia

Most serious adverse reactions were-

Allergic reactions including anaphylaxis < 1%

Rash < 1%     Hemolysis < 1%

Commonly observed serious adveres reactions-

Fever 4%,  neutropenia with  fever 3%     respiratory distress  2%    sepsis 2%        neutropenia 2%     mucositosis 2%

Histoy of anaphylaxis or hypersensitivity reactions-

Special Precautions/Warnings -

Anaphylaxis - Rasburicase may cause severe hypersensitivity reactions. including anaphylasis.

Rasbiricase should be immediately and permanently discontinued if any patient develops clinical evidence of a serious hypersensitivity reaction 

Hemolysis - Rasburicase administered to a patient with glucose -6-phosphate dehydrogenase  G6PD deficiency canncause severe hemolysis. It is recommended that patients at higher risk for G6PD deficiency be screened prior to starting therapy

Hydration- patients on rasburicase should receive IV hydration acording to standard medical practice for management of plasma uric acid in patients at risk for  tumor syndrome.

Pregnancy- Rasburicase should be given topregnant women only if required

Lactation- because of the potential risk to the fetus, adminster the drug only if it is important to the mother

Children- safety and efficacy of rasburicase not established in children.

Indication-

Hyperuricemia

Dosage-
0.15 or 0.2mg/kg as a single daily dose for 5 days.
Dosing beyond 5 days or administration of more than 1 course of rasburicase is not recommended

Do not adminster as a bolus infusion. Rasburicase should be administered as an intravenous
infusion over 30 minutes

Pregnancy-
Rasburicase should be given topregnant women only if required

Lactation-
Because of the potential risk to the fetus, adminster the drug only if it is important
to the mother

Children-
Safety and efficacy of rasburicase not established in children.