Antiarrhythmias /thioridazine - caution is adviced when arsenic trioxide is coadministered
with other medicines that prolong QT intervals or lead to electrolyte abnormalities
eg. diuretics, amphotericin B
Musculoskeletal- arthalgia 12% myalgia 9% bone pain 8% back pain 6%
Arsenic trioxide is contraindicated in hypersentive patients to arsenic
QT prolongation- QT.QTc prolongation should be expected during treatment with arsenic
Complete AV Block - has been reported with arsenic trioxide
Renal/hepatic function impairment =safety and effectiveness of arsenic oxide in patients with renal and hepatic impairment have not been studied
Pregnancy- women of child bearing potential should be adviced to avoid becoming pregnant
Lactation- decide whetherto discontinue nursing or the drug depending on the importance of the drug to the mother.
Children - safety and effectiveness in pediatric patients below 5 years have not been established
Monitoring- patients electrolyte, hemotalogic and coagulation profiles should be monitored
at least twice wekly and more frequently for clinically unstable patients during the induction
phase. Monitor ECG wekly and more frequently for unstable patients
Dosages/ Overdosage Etc:
Acute promyelocyte leukemia ( APL )
Dosage- arsenic trioxide should be administered intravenously at a dose of 0.15mg/kg until
bone marrow remision. Total induction dose should not exceed 60 doses
Consolidation dose - should begin 3 to 6 weeks after completion of induction therapy.
Arsenic trioxide should be administered intravenously at dose of 0.15mg/kg daily for
25 doses over a period of 5 weeks.
Storage - store at 25C ( 77F ) . Do not freeze.
Pregnancy and lactation:
Women of child bearing potential should be adviced to avoid becoming pregnant
Decide whetherto discontinue nursing or the drug depending on the importance of
the drug to the mother.
Safety and effectiveness in pediatric patients below 5 years have not been established
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