Drug interactions- summary

Androgens/estrogens/ progestins/or glucocorticoids-

gonadorelin test should be conducted  in the absence of other drugs that directly  affect
the pitutiary secretion of the gonadorelin.

Levodopa/and spironolactone -

gonadorolein  levels may be elevated by spironolactone and minimally by levodopa

Digoxin/and oral contraceptives -

gonadrorelin  levels may be suppressed  by oral contraceptives and digoxin

Phenothiazine and dopamine antagonists-

response of gonadorolin may be blunted by phenothiazine and dopamine antagonists
which cause rise in prolactin.

Gonadorelin test

Cardiovascular -   flushing

CNS -   headache,  lightheadeness

Dermatologic-   local swelling, pain and puritus at injection site, local skin rash after
                           chronic  subcutaneous administration 

GI -    nause, abdominal discomfort

Hypersensitivity -          rare bronchospasms, tachycardia, flushing,  urticaria, induration at
                                        injection site,  anaphylactic reactions

Miscellaneous -          pitutitary  apoplexy and sudden blindness following gonadrotropin
                                      releasing hormone administration to a patient with a gonadrotropin-
                                      secreting adenoma

Hypersensitivity to gondorelin or any of its components

Special Precautions/Warnings-

Antibody formation-   antibody formation reported after chronic administration of  large
doses of gonadorelin hydrochloride

Hypersensitivity - no reactions have been reported following a single 100mcg dose of
gonadorelin hydrochloride. Rarely reported with multi doses of gomadrolien hydrochloride

Pregnancy - drug should be used  during pregnancy only if needed.

Lactation- caution should be excercised when gonadorelin hydrochloride to breast feeding
woman.

Children-  safety and effectiveness in pediastric patients have not been established

Indication-

Gonadorelin test

Dosage-

Adults - 100mg mcg dose subcutaneously or intravenously. In female for whom the phase
of the menstrual cycle can be established the test should be performed in the early folicular
phase days ( days 1 to 7)

Storage-  store at room temperature  approx 77F .After reconstitution store at room temperature and use within 1 day. Discard unsed solution and diluent.

Pregnancy -
Drug should be used  during pregnancy only if needed.

Lactation-                                                                                                                            Caution should be excercised when gonadorelin hydrochloride to breast feeding
woman.

Children- 
Safety and effectiveness in pediatric patients have not been established