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Updated On: 18-11-2024

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Metyrapone -@ - IN VIVO Diagnostic Aids

Drug Name:
Metyrapone -@ - IN VIVO Diagnostic Aids

List Of Brands:

METOPIRONE *

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pregnancy and lactation

Drug Interaction:

Drug interactions -summary -

Corticosteroids -

drugs affecting pitutiary or adenocorticoal function including all corticosteroids therapy , must be discontinued prior to and during testing with metyrapone.

Phenytoin-

metabolism of metyrapone accelrated by phenytoin. Tests may be inaccurate in patients
taking phenytoin within 2 weeks before.

Indication:

Diagnostic aid

Adverse Reaction:

CNS - headache, dizziness, sedation

Dermatologic - allergic rash

GI - nausea, vomiting, abdominal discomfort, or pain

Hematologic- rarely decreased white blood cell count or bone marrow depression

Contra-Indications:

Hypersenstivity to metyrapone

Special Precautions/Warnings

Acute adrenal insufficiency - metyrapone may induce acute adrenal insufficency in patients with reduced adrenal secretory capacity.

Response to adrenals - ability of adrenals to respond to exogenous ACTH should be
demonstrated before mytyrapone is employed as test.

Hypo-hyperthyroidism - in presence of hypo-hyperthyroidism response to metyrapone
may be subnormal

Hazardous tasks- since metyrapone may cause dizziness, and sedation, patients should
excercise caution when driving or operating machinery.

Pregnancy- should be given to a pregnant only if required

Lactation- caution should be excercised when drug is administered to a breast feeing woman

Dosages/ Overdosage Etc:

Indication-

Diagnostic aid

Dosage-
single dose test - usually given as an outpatient-
30mg/kg maximum 3g metyrapone at midnight with yogurt or milk.
The same dose is recommended in children
The blood sample for the assay is taken in the morning (7;30 to 8am )
Plasma should be frozen as soon as possible
The patient is given a prophylactic dose of 30mg cortisone acetate

Patient Information:

Ref - USP PDI Vol II 17th Edition (1997)

1.Allergies-

Tell your doctor if you have ever had any unusual or allergic reaction to

metyrapone. Also tell your healthcare care professional if you are allergic to

any other substances such as foods. preservatives or dyes.

2.Pregnancy-

Metyrapone has not been fully studied in pregnant women. However, some

small studies have shown that metyrapone can affect the production of

chemicals by the pitutiary and adrenal glands of the fetus.

Before taking metyrapone make sure that your doctor knows that you are

pregnant or if you may become pregnant

3. Breast-feeding-

It is known not known whether metyrapone passes into breast milk.

However, use of metyrapone is not recommended during breast feeding

as it causes unwanted side effects in nursing babies.

4.Children-

This medicine has been tested in children and has not been shown to cause

different side effects or problems than it does in adults.

5.Older adults-

Although there is no specific information comparing use of metyrapone in the

elderly with use in other age groups, it is not expected to cause different side

effects or problems in older people than it does in younger adults

6. Other medicines-

Tell your doctor if you are using any of the following -

Alcohol

Barbiturates

Carbamazepine

Corticosteroids

Estrogens

Griseofluvin

Oral contraceptives

Phenylbutazone

Phenytoin

Primidone

Rifampicin

7. Other medical problems-

Make sure you tell your doctor if you have any other medical problems

especially-

Breast cancer or

Diabetes or

Heart disease

Liver disease or

Low blood sugar or

Thyroid disease - these conditions may cause false results of metyrapone

testing and resultin wrong diagnosis

Excessive body hair in female - long term therapy may increase growth

of body hair

Pophyria - metyrapone may worsen active cases of porphyria

Underactive adrenal or pituitiary gland- metyrapone may reduce the

amount of certain hormones produced by the adrenal glands , these

hormones are needed to respond to stress or illness.

Pregnancy and lactation:

Pregnancy-
Should be given to a pregnant only if required

Lactation-
Caution should be excercised when drug is administered to a breast feeing woman

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Disclaimer: Every effort has been made to ensure that the information provided in this Database is authentic and accurate. Commissions or omissions in the database, if any, are purely inadvertent and the site owner shall not accept any liability whatsoever for any adverse consequences of any nature arising to any individual or third party, as a result of usage of this information.