Drug Interaction- summary -

+ Histoplasmin

Cimetidine

cimetidine therapy may enhance or augument delayed hypersensitivity responses to
skin test antigens

Immunosuppressants , vaccine, virus

reactivity to any delayed hypersentivity test may be delayed in persons receiving
corticosteroids or any immunosuppresive drugs. Perform skin test preceeding or
simultaneously with immunization or 4 to 6 weeks after immunization

Histoplasmosis , diagnosis

Hypersensitivity -  urticaria, shortness of breath, and excessive prespiration may occur.

Local - in highly sentive individuals , ulceration, or necrosis may occur.and may result in scarring. Cold packs or topical steroid can employed for symptomatic relief of the associated pain, pruritus and discomfort

Known histoplasmin positive reactions because of severity of reactions

Special Precautions/Warnings-

Local reactions - dose greater than recommended dose may produce severe erythema

Administration- inject intradermally only. A separate sterile syringe and needle should
be used for each individual patient

Serological studies - if serological  studies are clinically indicated the blood sample  should be preferably drawn prior to administering skin test.
If the sample is not obtained prior to skin testing it may be obtained within 48 to 96 hours
following skin test injection.

Hypersensitivity reactions- epinephrine should be immediately available in case an anaphyloid or acute hypersentivity occurs.

Pregnancy - histoplastin should be given to a pregnant women only if clearly needed

Lactation- no information regarding histoplasmin in  breast feeding women available

Children -  safety and effectiveness in pediatric patients have not been established.

Indication-

Histoplasmosis , diagnosis

Dosage-
skin test is performed by injecting 0.1ml intradermally into the flexur surface of the forearm.
The site of injection is first cleansed with 70% alcohol and allowed  to dry.
A tuberculin syringe one that has not been used for tuberculin is used

Pregnancy -
Histoplastin should be given to a pregnant women only if clearly needed

Lactation-
No information in breast feeding women available

Children - 
Safety and effectiveness in pediatric patients have not been established.