Paracetamol-

Reduced absorption  of cholestyramine  within 1 hour of administration

Accelerated  absorption with metoclopromide

Decreased effects of barbiturates, carbamazepines, hydantoins, ripampicin,
and sulfinpyrazone

Paracetamol increase effect of warfarin

Paracetamol increase risk of liver damage in chronic alcoholics ,

Increased risk of toxicity with other hepatotoxic drugs or drugs which induce
microsomal enzymes eg. barbiturates , carbamazepine , hydantoins,
ripampicin, sulfinpyrazone

Moderate to severe pain

Nausea,    allergic reactions,   skin rashes,   acute renal tubular necrosis

Very rare dyscrasias eg. thrombocytopenia, agranulocytosis, liver damage

Special precautions/warnings-

Renal or hepatic impairment

Alcohol-dependent patients

G6PD deficiency

Indication-

Moderate to severe pain

Dosage-
Paracetamol-

Adult- 0.5 to 1g 4-6 hourly as necessary. Max  4g daily

Child-  neonate- 28 to 32 weeks
 post menstrual age- 20mg/kg as a single dose
then 10-15mg /kg  8-12 hourly  ( max 60mg/kg  daily in divided doses

Child - 1-3 mths - 30mg  8 hourly (max 60mg/kg daily in divided doses )

3mth to 1 year - 60-120mg 4-6 hrly 9max 4 doses in 24 hours

1-5 years - 120-250mg 4-6 hourly  (max 4 doses  in 24 hours )

6-12 years - 250- 500mg 4-6 hourly 9max 4 doses  in 24 hours