Drug Interactions- Summary

Bisphosponates - Alndronat, Etidronate, Risedronate -

concomittant intake of a bisphosphonate and calcium may decrease the absorption of
bisphosphonate

H2 receptor blockers - Cimetidine, Famotidine, Ranitidine -

concomittant use of H2 receptors blockers and calcium aspartate can cause decreased
absorption of these salts

Levoththyroxine -

concomittant intake of levothroxine and calcium aspartate reduce levothyroxine absorption
and to increase serum thyrotropin levels.
Levothyroxine may absorb calcium aspartate in an acidic environment whic may block
absorption

Proton pump inhibitors- Lanzoprazole, Omeprazole,Rabeprazole sodium-

concomittant use of proton pump inhibitors and calcium aspartate can cause decreased
absorption of these calcium salts.

Quinolones - Ciprofloxacin, Gatifloxacin, Levifloxacin, Lemofloxacin, Moxifloxacin,
Norfloxacin, Ofloxacin, Sparfloxacin, Trovafloxacin, 

concomittant use of a quinolone and calcium aspartate  may decrease  the absorption
of the quinolones

Tetracyclines - Doxycycline -

concomittant intake decrease the absorption of Tretracycline.Tetracycline may form 
non-absorbale complexes with calcium

Vitamin D analogs- Calcitrol, Alfacalcitrol-

concomitant use of these Vitamin D analogues  and Calcium aspartate  increased  absorption of calcium

Osteoporosis
Bone fracture
Osteoarthritis

Generally well tolerated.

In some cases, may cause
constipation,    bloating,     gas,    flatulence,    abdominal pain,

thirst,   polyuria,   confusion   and delirium.

Contraidicated in the following conditions-

Renal calculi,   Hypercalcaemia,  Hyperparathyroidism,   Hypervitaminosis D
Cancer,  Hypersensity to the drug or the ingredients

Special Precautions/Warnings-

Supplemental calcium without food may increase risk of kidney stone in women and also in men

Supplemental calcium without food limits the oppurtunity  for the beneficial effects that
calcium have in binding oxalate in the intestine.
It is recommended that supplemental Calcium aspartate be taken with food

Those at risk of Calcium containing  kidney stones are generally adviced not to take
supplemental calcium.

Those with achlorhydria should take Calcium aspartate with food
 

Indication-

Osteoporosis
Bone fracture
Osteoarthritis

Dosage -

Macrozorb 560mg tabs-  
Adults and Children 12 years and over - one tablet twice daily or two tablets once daily.
The dosage can be increased  up to two tablets three tablets a day

Macrozorb Forte  1120mg tablets-
Adults and Children 12 years and over - one tablet daily. The dosage can be increased
up to  one tablet three times a day

It is recommended that supplemental Calcium aspartate be taken with food