Antihypertensive effects of hypotensive agents may be reduced
May increase cyclosporin levels

Increased risk of seizures with fluroquinolones
May reduce efficacy of diuretics

May diminish cardioprotective effects of acetylated salicylates 
May increase lithium levels/toxicity

Severe bone marrow suppression, aplastic anemia,
and GI toxicity may occur with methotrexate

Rheumatic disorders

Odema, palpitation, dizziness, drowsiness, headache,  vertigo,

pruritus, skin eruption, ecchymosis, purpura, rash,

fluid retention,  abdominal pain, constipation, nausea, heartburn

diarrhoea, dyspepsia, diarrhoea, stomatitis, flatulance,

indigestion, ulcers, abnormal renal function

 Hypersensitivity
Aspirin or NSAIDs allergy,
Perioperative pain in settiing of CABG  surgery
Pregnancy ( 3rd semester )

Special Precautions/warnings-
Pre-existing CV factors, or disease eg fluid etention, CHF , hypertension,
History of GI disease ( bleeding or ulcers )
other forms of asthma,
hepatic impairment
Closely monitor patients with abnormal LFT
Renal impairment
Elderly
Lactation

Indication-

Rheumatic disorders

Dosage-
Initially 500mg followed by 250mg every 6-8 hours as adviced by the physician

Use contraindicated. Observe caution