Cytochrome P450 -

Excercise caution when coadministering celecoxib and mefenamic acid with drugs known
to inhibit the isoenztme 2C9

Drug interactions - summary-

NSAIDs +

Methotrexate

risk of methotrexate toxicity eg stomatitis, bone marrow suppresion, nephrotoxicity may
be increased . Celecoxib and meloxicam  did not have a significant effect on methotrexate
pharmacokinetics

NSAIDs - indomethicin + Penicillamine

indomethicin may increase bioavailibility of penicillinamine

NSAIDS - indomethicin./ diclofenac

effects of potassium spaing -diuretics decreased. Co-admin may increase serum potassium levels.

Thiazide diuretics

decreased anti-hypertensive and diuretic action of thiazides may occur with concurrent
indomethicin. Naproxen also included. Sulindac may enhance effects of thiazide

Non-steroidal anti-inflammatory drug -associated gastric ulcers

Refer - Naproxen and Lansoprazole

Refer - Naproxen and Lansoprazole

Indication-

Non-steroidal anti-inflammatory drug -associated gastric ulcers

Dosage-

Usual dosage- each daily dose consists of one lansoprazole 15mg capsule and two of either
naproxen 375mg or 500mg tablets

Refer - Naproxen and Lansoprazole