Naproxen / Lanzoprazole - NSAIDs Combinations
Drug Name:
Naproxen / Lanzoprazole - NSAIDs Combinations
List Of Brands:
Indication Type Description:
Drug Interaction:
Cytochrome P450 -
Excercise caution when coadministering celecoxib and mefenamic acid with drugs known
to inhibit the isoenztme 2C9
Drug interactions - summary-
NSAIDs +
Methotrexate
risk of methotrexate toxicity eg stomatitis, bone marrow suppresion, nephrotoxicity may
be increased . Celecoxib and meloxicam did not have a significant effect on methotrexate
pharmacokinetics
NSAIDs - indomethicin + Penicillamine
indomethicin may increase bioavailibility of penicillinamine
NSAIDS - indomethicin./ diclofenac
effects of potassium spaing -diuretics decreased. Co-admin may increase serum potassium levels.
Thiazide diuretics
decreased anti-hypertensive and diuretic action of thiazides may occur with concurrent
indomethicin. Naproxen also included. Sulindac may enhance effects of thiazide
Indication:
Non-steroidal anti-inflammatory drug -associated gastric ulcers
Adverse Reaction:
Refer - Naproxen and Lansoprazole
Contra-Indications:
Refer - Naproxen and Lansoprazole
Dosages/ Overdosage Etc:
Indication-
Non-steroidal anti-inflammatory drug -associated gastric ulcers
Dosage-
Usual dosage- each daily dose consists of one lansoprazole 15mg capsule and two of either
naproxen 375mg or 500mg tablets
Pregnancy and lactation:
Refer - Naproxen and Lansoprazole