Drug interactions -summary

HMG-CoA  reductase inhibitors-
inhibitors of HMG CoA may cause myopathy that is manifested by muscle pain oe weaknening
associated with elevated levels of CPK .
Therefore consider tempororary suspension of of use of HMG-CoA reductase inhibitors in
patients receiving daptomycin

Warfarin-
Monitor anticoagulant activity in patients receiving daptomycin and warfarin for the first
several days after initiating therapy

Adverse reactions-

Cardiovascular -   Hypertension, hypotension

CNS-  Headache, insomnia

Dermatologic - Pruritus, rash

GI - Constipation, dyspepsia, nausea, vomiting

Lab test abnomalites- abnormal liver enzyme tests, elevated  CPK

Musculoskeletal -  arthalgia, limb pain

Miscellaneous- anemia ,dyspnea, fever, fungal infections, injection site reactions
                           urinary tract infections

Hypersensitivity to the drug

Special Precautions/warnings-

Pseudiomembraneous colitis- has been reported with all antibactetial agents including
daptomycin. Consider diagnosis in patients who present diarrhea subsequent
to the administration of ant antibacterial agent.

Superinfection- use of antibiotcs may promote over growth of nonsuseptible organisms.
If superinfection occurs during therapy, take appropiate measures.

Pregnancy- use this drug during pregnancy only if clearly needed

Lactation- excercise caution when administering daptomycin to a breast feeding woman.

Children- safety for use in patients younger than 18 years of age have not been studied

Elderly - Treatment emergent adverse reactions more common in patients of 65 age of age and above.

Indication-

Skin and skin structure infections

Dosage-
Adults- 4mg/kg by IV infusion over 30 minutes once every 24 hours for 7 to 14 days

1. Advice patients to report to their doctor,any signs of muscle pain r weakness , particularly
   in the distal extremities

2. Advice patients to report severe diarrhea, stomach pain/cramps or bloody stools to their doctor.

Pregnancy-
Use this drug during pregnancy only if clearly needed

Lactation-
Excercise caution when administering daptomycin to a breast feeding woman.

Children-
Safety for use in patients younger than 18 years of age have not been studied

Elderly -
Treatment emergent adverse reactions more common in patients of 65 age of age and above.