Drug interactions- summary-

Metoclopromide-
when coadministered, metoclopropamide increase gastro-intestinal motility, lowers the serum
concentration and urinary excretion of fosfomycin .

Cimetidine -
cimetidine does not affect the pharmcokinetics of fosfomycin when coadministered

Urinary tract infections

Adverse reactions-

CNS-  headache  9% nervousness, somnolence, parathesia, insomnia , migraine ( < 1%)

GI - diarrhea  9%  nausea, 4%, dyspepsia, 1.2%
        abnormal stools, dry mouth, flatulence,anorexia, constipation, vomiting < 1% )

Dermatologic -   rash 1.2%   skin disorder, pruritus < 1% )

GU - vaginitis 6% dysmenorrhea, 2%, hematuria, menstrual disorder, dysuria, < 1%

Respiratory - rhinitis 4%, pharyngitis 2%

Miscellaneous- back pain 2.5% dizziness ,abdominal pain,pain 2% , asthenia 1.5%
                           myalgia, ear disorder, fever, flusyndrome, infection, lymphadenopathy,
                           AST increase, < 1%

Hypersensitivity

Special Precautions-

Acute cystitis- do not use more than 1 single dose of fosfomycin tromethamine to treat single
episode of acute cystitis. Repeated dose did not improve conditions, but increased incidence of
adverse reactions

Pregnancy- To be used during pregnancy only if clearly needed.

Lactation- decide whether to discontinue nursing or the drug taking into consideration the
importance of the drug to the mother.

Children- safety and efficacy for use in children 12 year and under have not been established

Elderly- start at a low dose, reflecting the greater frequency of decreased hepatic, renal,
or cardiac function

Indication-

Urinary tract infections

Dosage-
Women - 3g ( 1 sachet ) as a single dose

1.Fosfomycin can be taken with or without food.

2. Symptoms should be improved in 2 to 3 days, if not patient should contact her doctor

Fosfomycin can be taken with or without food.

Pregnancy-
To be used during pregnancy only if clearly needed.

Lactation-
Decide whether to discontinue nursing or the drug taking into consideration the
importance of the drug to the mother.

Children-
Safety and efficacy for use in children 12 year and under have not been established

Elderly-
Start at a low dose, reflectingg the greater frequency of decreased hepatic, renal,
or cardiac function