Drug interactions - summary-

+ Raltegavir

Alatazanavir -
no dose adjustment is recommended

Efravirenz -
efravirena reducesplasma concentration of raltegravir

Etravarine-
etravarine reduces plasma concentration of raltegravir

Omeprazole-
coadmin increase gastric pH increased raltegravir solubility. No dosage adjustment is
recommended

Rifampin-
recommended dosage is 800mg twice during coadmin with rifampin. Use caution

Tipranavir/rotonavir -
reduces plasma concentration of raltegravir , No dosage adjustment recommended

New Drugs Approved by (DCI) Drug Controller  GENERAL -  India  For Marketing                                                                                            (Ref- IDMA Publication)

Raltegravir -  Integrase Inhibitors - Antiviral agents

HIV infection

Adverse reactions-

CNS -     asthenia  2%    fatigue   2%   headache 3%

GI -    nausea    2%

Not known

Special precautions-

Pregnancy - use raltegravir only if the potential benefit justifies  the risk to fetus.

Lactation- breast feeding is not recommened while taking raltegravir

Children - safety and efficacy studies have not been established for children below 16 years
 of age.

Elderly - use caution while administering to elderly patients because of greater frequency of
decreased hepatic , renal, or cardiac function and of concomittant disease or other drug therapy

Monitoring- monitor CD4+ cell count, and HIV RNA load

Indication-

HIV infection

Dosage-                                                                                                                                                           400mg twice daily
Concomittant therapy - during coadmin with rifampin  the recommended dose
of rategavir is 800mg twice daily.

Children > 16 years adult dose

1. Inform patients that raltegravir is not cure for HIV infections or AIDs and that they can still get  infection or other common conditions in people with HIV ( oppurtunistic infections )

2. Instruct patients that they should  practice safe sex

3. Instruct patients thy take the medications daily as precribed by their doctor.

Pregnancy -
Use raltegravir only if the potential benefit justifies  the risk to fetus.

Lactation-
Breast feeding is not recommened while taking raltegravir

Children -
Safety and efficacy studies have not been established for children below 16 years
 of age.

Elderly -
Use caution while administering to elderly patients because of greater frequency of
decreased hepatic , renal, or cardiac function and of concomittant disease or other drug therapy