Methadone, antihypertensives

Chronic idiopathic constipation
Irritable bowel syndrome

Adverse reactions-

CNS - dizziness , fatigue  < 1%,    heaache  4%

GI -  abdominal distention 2%  abdominal pain 3%  diarrhea, dry mouth, dyspepsia   <1%
        nausea 3%

Known hypersensitivity to the drug, history of technical GI obstruction

Special Precautions-
GI effects-  do not administer to who have severe diarrhea

Dyspnea- dyspnea has occurred  in patients treated with 24mcg, but generally resolve itself
with few hours. If it persists discontinue treatment.

GI  obstruction- evaluate patients with symptoms suggestive of mechanical GI obstruction
prior to initiating lubiprostone treatment

Pregnancy- use lubiprostone during pregnancy only only if potential benefit justifies the
potential risk to fetus.

Lactation- decide whether to discontinue breast feeding  or the drug dependending of
the importance to the mother

Children- safety and efficacy in children have not been established

Elderly- efficacy of lubiprostone in elderly patients over 65 years was consistent with the
overall with other patients
 

Indication-
Chronic idiopathic constipation
Irritable bowel syndrome

Dosage-
24mcg taken daily orally with food water

Irritable bowel syndrome with constipation-
8mcg taken twice daily orally with food and water

To be taken with food and water

To be taken with food and water

Pregnancy-
Use lubiprostone during pregnancy only only if potential benefit justifies the
potential risk to fetus.

Lactation-
 Decide whether to discontinue breast feeding  or the drug dependending on
the importance to the mother

Children-
Safety and efficacy in children have not been established

Elderly-
Efficacy of lubiprostone in elderly patients over 65 years was consistent with the
overall with other patients