Quinapril- @ACE(angiotensin converting enzyme) inhibitors- (FDC- List )- (Nov 1991)
Drug Interaction:
ACE inhibitors include- Benazepril, Captopril, Enalapril, Enalaprilat, Fosinopril, Lisonopril, Moexipril, Perindopril, Quinapril, Ramipril, Trandolapril
Refer Captopril
Interacting drugs - summary
ACE inhibitors + Potassium salts- concurrent use result in elevated serum potsssium concentrations in certain patients
Quinalapril + Tetracycline-
tetracycline absorption reduced possibly due to high magnesium
content of quinalapril tablets
Indication:
Hypertension, adjunct therapy in management of CHF
ACE inhibitors include- Benazepril, Captopril, Enalapril, Enalaprilat, Fosinopril, Lisonopril, Moexipril, Perindopril, Quinapril, Ramipril, Trandolapril
Refer Captopril
Approved by FDA in November 1991
Patent Expiry Date of drugs (Ref - IDMA Publication)
Chemical Category Manufacturer/ US Patent
Ingredient- Marketer Expiration Date
Quinapril Cardiovascular Hoechst AG 03-10-2002
New Drugs Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
1.Quinapril Anti-hypertensive 19-09-2002
2.Quinapril 20mg
+ HCTZ 25mg Film coated tablet 26-02-2009
For the treatment of Mild to Moderate Hypertension in Adult patients
(in whom combination therapy is appropiate ) who have been stabilized
on the individual component given in the same proportion
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
Quinalapril HCL eq.to 10-02-2003
Quinapril 10mg/20mg +
Hydrochlothiazide 12.5mg/12.5mg
Film coated tablet
For mild to moderate hypertension
Dosages/ Overdosage Etc:
Approved by FDA in November 1991
Indications: Hypertension, adjunct therapy in management of CHF
Dosage:
Initial dose- 10mg once daily. Adjust according to blood pressure response Maintenance- most patients require 20, 40, or 80mg/day as a single or in two equally divided doses.
Missed dose-
1. If you miss a dose of this medicine, and remember within 6 hours of take it as soon as possible unless the dose is less than 4 hours.
2. However, if you do not remember until later, skip the missed dose and go back to your regular dosing schedule.
3. Do not double doses.
Other Information:
List of entries
1. Congestive Heart Failure (CHF)
2. Atrial Fibrillation
3. Atrial Flutter
1. Congestive Heart Failure (CHF)
Heart failure is charaterized by well known symptoms and physical signs. Heart failure is
coinsidered to be pathophysiological state in which an abnormal cardiac function is responsible for the failure of the heart to pump blood at a rate communsurate with the requirement of the metabolizing tissues. Heart failure is frequently but not always caused by a defect in myocardial contraction, and then the term myocardial failure is appropiate,.
Increased cardiac output results in in diuresis and general amelioration of disturbances
characteristic of fight heart failure (venous congestion, edema) and left heart failure ) dyspnea, orthopnea, cardiac asthma). Digitalis is generaly most effective in "low output" failure and less effective in "high output " failure ) bronchopulmonary insufficiency, artriovenous fistula, anemia,
hyperthyroidism.
2. Atrial fibrillation
This is a dysrhythmia in which the effective contraction of the atria is abolished and the AV node and the ventricles are bombarded with a very rapid and irregular series of stimuli. Many of these impulses are blocked at the AV node, but many are passed through, so that the ventricular contracrtions in the untreated patient are usually rapid and irregularly irregular.
Digitalis rapidly reduces ventricular rates and eliminates the pulse deficit. Palpitation,precordial distress or weakness are relieved and concomittant congestive failure ameliorated. Continue digitalis in doses necessary to maintain the desired ventricular rate, both ar rest and in response to excercise and other clinical effects.
3. Atrial flutter
The dysrhythmia is less common than artial fibrillation. There is a considerable controversy
regarding its mechanism. A reciprocating rhythm or circus current movement is most likely. The atria contracts at a rate of 250 to 350 rates per minute. AV block is almost always present and its ratio is usually even numbered.
Digitalis slows the heart; normal sinus rhythm appear. Digitalis slows the ventricular rate, by decreasing the degree of AV block, and commonly converts flutter to fibrillation. When the drug is withdrawn , the atrial flutter will frequently revert spontaneosuly to normal sinus rhythm. If this not occur quinidine may be employed to restore sinus rhythm.
Heart Failure
Evidence Based Medicine (MIMS March 2003)
Beneficial
ACE inhibitors such as captopril, enalapril,lisonopril,and perindopril
Digoxin
Appropriate use of beta-blockers
Spironolactoone in severe cases
Likely to be beneficial
Multidisciplinary intereventions (nutrition, counselling)
Excercise
Angiotensin II receptor blockers
Amiiodarone
Implatable cardiac defibrillators
Unlikely to be beneficial
Calcium channel blockers
Likely to beineffective or harmful
Positive inotropes(non-digitalis)
Non-amiodarone antiarrhythmic drugs
Key Points
1. There is conflicting evidence of the efficacy of multidisciplinary approach
2. Pescribed excercise training improves functional capacity and quality of life and reduces the rate of adverses cardiac events
3. Ace inhibitors reduce mortality, admission to hospital for heart failue and ischaemic events in patients with heart failure but are still under-used.
4. One critical trial has found that angiotensin II receptor blockers are at least as effective as ACE inhibitors for reducing clinical events(death or admission to hospitals). They confer no advantage over ACE inhibitors but can be useful if ACE inhibitors are not tolerated
5. Positve inotropic drugs improve symptoms but do not reduce mortality
6. Adding beta-blocker to ACE inhibitors decreases the rate of death and admission to hospitals
7. One clinical trial has found that in severe heart failure, adding an aldosterone receptor antagonist to an ACE inhibitor reduces mortality compared with ACE inhibitors alone.
8. ACE inhibitors delay the onset of symptoms and reduce cardiovascular events in patients with asymtomatic left ventricular systolic dysfunction
Patient Information:
ACE inhibitors include- Benazepril, Captopril, Enalapril, Enalaprilat, Fosinopril, Lisonopril, Moexipril, Perindopril, Quinapril, Ramipril, Trandolapril Refer Captopril
1. Take captopril 1 hour before meals. Take moexipril in the fasting state
2. Do not interupt or discontinue medication without consulting physician
3. Notify physician if any of the following occur- sore throat, fever, swelling of hands or feet, irregular heart beat , chest pains, signs of angioedema, excessive prespiration, dehydration, vomiting and diarrhea may lead to a fall in blood pressure
4. May cause dizziness, fainting or lightheadedness, especially during the first days of therapy; avoid sudden changes in posture. If syncope occurs, discontinue drug until physician has been contacted. Heart failure patients should avoid rapid increases in physical activity.
5. May cause skin rash or impaired taste perception. Notify physician if these persist.
6. Do not use salt substitutes containing potassium without consulting a physician
7. A persistent dry cough may occur and usually does not subside unless the medication is stopped. If this effect become bothersome, consult a physician.
Pharmacology/ Pharmacokinetics:
Refer Ramipril - ACE inhibitors
Interaction with Food:
Refer Ramipril- ACE inhibitors
Pregnancy and lactation:
Refer- Ramipril- ACE inhibitors
