Naltrexone-  coadmin of naltrexone with acampostate produced an increase in AUC.

No dosage adjustments of dosage is recommended in such patients

CNS - 38%-    anxiety 7%  depression 7%   dizziness 3%   dry mouth  3%   insomnia 8%

Dermatologic - 7%    pruritus  3%   sweating 2% 

GI -   20%  -   anorexia 4%   diarrhea 10%   nausea  3%

Miscellaneous - 30%     accidental injury  3%   asthenia  6%  pain 2%

Hypersensity to the drug

Special Precautions-

Withdrawal symptoms-  use of acamprosate does not eliminate or diminish withdrawal symptoms

Suicide-  Alert families of patients being treated with acomposate of the need to monitor patients 
for the emergence of depression or suicidality and to report such symptoms to their doctor.

Pregnancy- use acomprosate during pregnancy only if the potential benefit justifies the potential
risk to the fetus.

Lactation- excercise caution when acomprosate is administered to a woman who is breast feeding

Children- safety and efficacy of acamposate in children is not established  

Elderly- use care in dose selection , it may be useful to monitor renal function.

Indication-

Alcoholism

Dosage-
Adults- two 333mg tablets ( each dose should total 666mg )  given 3 times a day.
A lower dose may be effective in some patients

Elderly- because elderly patients are more likely to have decreased renal clearance, use
care in dose selection.

Renal function impairment- for patients with moderate renal impairment ( creatinine clearance
CrCl 30 to 50mL/min ) a starting dose of one 333mg tablet 3 times daily is recommended.

Do not give acamposate calcium to patients with severe renal impairment
(CrCl  30mL/min or less )

Although dosing may be done without regards to meals, during clinical trials dosing with
meals was employed. It was suggested as an aid to compliance in those patients
 who regularly eat 3 meals daily. 

1. The drug may impair judgement, thinking, or motor skills

2. Caution patients about operating hazardous machinery  including automobiles, unitl
    they are reasonably certain that acomprosate therapy does not affect their ability to
    engage in such  activites.

Can be taken with meals if required

Pregnancy-
Use acomprosate during pregnancy only if the potential benefit justifies the potential
risk to the fetus.

Lactation-
Excecise caution when acomprosate is administered to a woman who is breast feeding

Children-
Safety and efficacy of acamposate in children is not established  

Elderly-
Use care in dose selection , it may be useful to monitor renal function.