Emphysema

Prolastin - delayed fever ( max temp rise was 38.9 C, resolved spontaneously after 24 hours

Mild transcient leukocytosis and dilutional anema several hours after infusion have also been noted.

Severe reactions including anaphylaxis have occured

Special Precautions-
Possibility of unknown infectious agents may be present because alpha P1 is derived from pooled
human plasma . It may carry risk of transmitting infectious agents eg viruses .

Patients may develop signs and symptoms of some viral infection, particularly hepatitis C

All signs and symptoms of infections should be reported.

Circulatory overload-  there will be an increase in plasma volume following IV administration.
Use caution in patients at risk of circulatory overload

Hepatitis B immuninazation- it is recommended that in preparation of patients for receiving Prolastin,
recipients be immunized against hepatitis B using hepatitis B vaccine.

Hypersensitivity reactions- if anaphylactic or severe anaphylactoid reactions occur, discontinue
infusion immediately. Ephedrine or other appropiate supportive therapy should be made available

Pregnancy- use only when clearly needed and when the potential benefit outweighs the potential
risk to the fetus.

Lactation- excercise caution when administering to a nursing woman

Children- safety and efficacy for use in children not established

Indication-
Emphysema

Dosage-
Recommended dosage is 60mg/kg/ body weight administered by IV injection

For IV use only- give at the rate of approx 0.08ml/kg/min as determined by the response
and comfort of patient. The infusion should take approximately 15 to 30  minutes to cpmplete

1. Inform patients of the signs and symptoms of hypersensitivity reactions including hives,
   generalized urticaria, tightness of the chest, dyspnea, wheezing, faintess, hypotension,
   and anaphylaxis

2. Advice patients to discontinue use and report to the doctor immediately if any hypersensitivity
    reactions takes place.

Pregnancy-
Use only when clearly needed and when the potential benefit outweigh the potential
risk to the fetus.

Lactation-
Excercise caution when administering to a nursing woman

Children-
Safety and efficacy for use in children not established