Intestitial cystitis

A garlic like taste may noted by  the patient a few minutes within after instillation
of dimethyl sulfoxide . This taste may last several hours and because of the presence of
metabolites , an odor on the breath and skin may remain for 72 hours

Patient may may experience moderately severe discomfort on administration.Usually this
becomes less prominent with repeated administration.

Special precautions-
Changes in refractive index-  changes in refractive index and lens opacities have been seen in
monkeys. dogs, and rabbits given at high doses of dimethyl sulfoxide

Since lens changes have been noted in animals, full eye evaluation , including slit lamp
examination are recommended prior to and periodically during treatment

Approximately every  six months patients receiving dimethyl sulfoxide should have a biochemical
screening ,particularly liver and renal function tests and complete blood count.

Intravesical instillation of dimethyl sulfoxide may be harmful to patients with urinary malignancy
because dimethyl sulfoxide - induced vasodilation

Hypersensitivity reactions- dimethyl sulfoxide can intiate the liberation of histamine and  occassional
hypersensitivity reactions have been noticed. If anaphylactoid reactions develop appropiate therapy
should be instituted

Pregnancy- should be used during pregnancy only if needed

Lactation- caution should be excercised when dimethyl sulfoxide is administered to a nursing
woman

Children-  safety and effectiveness in children have not been established

Indication-
Intersitial cystis

Dosage-
Instillation of 50ml of dimethyl sulfoxide directly into bladder may be accomplished by catheter
or aseptic syringe and allowed to remain for 15 minutes

Application of analgesic lubricant gel such as lidocaine jelly to the urethera is suggested
prior to insertion of the catheter to avoid spasm. The medication is expelled by voiding

It is recommended that the treatment is repeated every two weeks until maximum symptomatic
relief is obtained

Administration of oral analgesic medication or suppositories containing belladonna and opium
prior to instillation of dimethyl sulfoxide can reduce bladder pain

Dimethyl sulfoxide should not be given IM or IV.

1. Dimethyl sulfoxide will be instilled in the bladder on an impatient  or out patient basis, which will
    be determined by the physician

2. Tell your doctor about the drugs and dosage of all medications you are taking  before
    dimethyl sulfoxide instillation.

3. A garlic like taste may be noted by the patient within a few minutes after instillation of
    dimethyl sulfoxide. This taste may last for several hours . An odor of the breath and skin
    may be present and remain for upto 72 hours.

4. If  you are pregnant , ask your physician about the feasibility of using dimethyl sulfoxide

5. Some eye changes have been observed in animals treated with dimethyl sulfoxide. Therefore
   your doctor may want you to have eye evaluation, including slit lamp examination prior
   to and periodically during treatment.

Pregnancy-
Should be used during pregnancy only if needed

Lactation-
Caution should be excercised when dimethyl sulfoxide is administered to a nursing
woman

Children- 
Safety and efectiveness in children have not been established