Congestive heart failure

Cardiovascular -   hypotension 10%   symptomatic hypotension 4%   asymptomatic hypotension 7%
                               ventricular tachycardia  4%      non sustained VT 4% 
                               ventricular extrasystole  1%    angina pectoris  2%

CNS -                    insomina  3%     dizziness 2%      anxiety 3%

GI -                       nausea   5%       vomiting 2%

Miscellaneous-     headache  20%     abdominal pain 4%     back pain  3%

Hypersensitivity to the components

Special precautions-                                                                                                                            Low cardiac filling pressure-    admin of nesiritide should be avoided in
patients suspected of having known to have low cardiac filling pressures

Cardiovascular -  nesitiride nay cause hypotension

Renal effects- nesiritide may affect renal function in susceptible individuals .
In patients with severe heart failure whose renal function may depend on the activity of
renin-angiotensin- aldosterone system treatment with nesiritide may be associated with azotemia

Hypersensitivity reactions-  no serious allergic or anaphylactic reactions have been reported with
nesitiride

Special risk- nesiritide is not recommended for patients for whom vasodilating agents are not
appropiate, such as patients with significant valvular stenosis

Pregnancy - use during pregnancy only if the potential benefit justifies any possible risk to fetus.

Lactation- caution should be excercised when nesiritide is administered to a breast-feeding woman

Children - safety and efficacy of nesitride in children have not been established

Indication-
Congestive heart failure

Dosage-
Recommended dose of nesiritide is an IV bolus of 2mcg/kg followed  by a continuous infusion
at a dose  of 0.01mcg/kg/min .
Nesiritide should not initiated at a dose that is above the recommended dose

Pregnancy -
Use during pregnancy only if the potential benefit justifies any possible risk to fetus.

Lactation-
Caution should be excercised when nesiritide is administered to a brest-feeding woman

Children -
Safety and efficacy of nesiritide in children have not been established