Type II Diabetes not responsive to diet

Indication-
Type II Diabetes not responsive to diet

Dosage- 
Maximum dose -  pioglitazone 45mg/glimepiride 8mg per day.

Elderly- initial dose  dosing, dose increments and maintenance dose  should be conservative to
avoid hypoglycemic reactions. The initial dose should be started at glimepride 1mg prior to
prescribing pioglitazone/glimepride.

Renal function impairment- the initial starting dose at glimepride 1mg  prior to prescribing
pioglitazone/glimepride,.

Hepatic function impairment-   the dose dose should be started at glimepride 1mg prior to
prescribing pioglitazone/glimepride,

Debilated /malnourished patients.- the initial starting dose at glimepride 1mg  prior to prescribing
pioglitazone/glimepride,.

Congestive heart failure and hypertension- the lowest approved dose of pioglitazone/glimepride
therapy should be prescribed

Administration- once daily with the first meal of the day