Beta-adrenergic blockers include-

Atenolol, Acebutol, Betaxolol, Bisoprolol,Cartelol,Esmolol, Labetatol,Metoprolol, Nadolol,Penbutolol, Pinodol, Propranolol, Sotatol, Timolol,

Refer - Atenolol

Concomittant general anaesthesia,may impair myocardial contractility

.Polymorphic ventricular tachycardia with antidepressants and quinidine.

Food and milk reduces bioavilability.

Supraventricular and ventricular tachycardia 

Beta-adrenergic blockers include- Atenolol, Acebutol, Betaxolol, Bisoprolol,Cartelol,Esmolol, Labetatol,Metoprolol, Nadolol,Penbutolol, Pinodol, Propranolol, Sotatol, Timolol,

Refer - Atenolol

Polymorphic ventricular tachycardia(very rare).

Nausea,insomnia,lassitude,diarrhoea, masks early signs of hypoglycaemia,bradycardia,cardiac arrhythmias.rebound angina,arrhythmias or ever M.I. if withdrawn abruptly.

Patients with heart-block or history of bronchospasm & poor cardiac reserve,diabetic ketoacidosis and metabolic acidosis.

Special precautions::

The drug may reduce or mask the pre-hypoglycaemic warning signs in treated diabetes.

Withdraw the drug gradually.

Pregnancy,lactation. Reduce dosage in renal insufficiency. History of asthma.Monitor plasma electrolyte concentration before and during therapy.

Indication-

Supraventricular and ventricularv tachycardia

Dosage-

80mg daily as a single dose or in 2 divided doses increased gradually every 2-3 days Usual dose - 160- 320mg daily in 2 divided doses maximum 640mg

Child- neonates- initially 1mg/kg bid increased every 3-4 days if necessary

Maximum- 1mth - 12 year- 1mg/kg bid increased if necessary every 2-3 days

Life threatening ventricular arrhythmias- adult- 480 - 840 mg daily

Refer - Atenolol

AVOID CONCURRENT USE WITH ERYTHROMYCIN

Refer- Atenolol- Beta adrenergic blocker

Absorption may be reduced by food especially by milk.

Refer- Atenolol- Beta adrenergic blocker