Potassium supplements or potassium rich diet,ACE inhibitors,general anaesthetics(reduced
vascular responsiveness to catecholamines),lithium.

Aminoglycosides and ethacrynic acid(increased ototoxicity), tubocurazine,succinylcholine
(effects enhanced).
Sucralfate reduces effects of frusemide.Should be given 2 hour apart.

NSAIDs reduce natriuretic and antihypertensive effects of frusemide .
Corticosteroids may antagonise action.

Digoxin levels may be increased.
Warfarin effects may be reduced.

Refractory edema Hypertension associated with secondary hyperaldeosterronism

Severe hyperkalaemia in patients with pre-existing renal impairment or taking
ACE inhibitors, agranulocytosis, cardiac arrhythmias.

Fluid and electrolyte imbalance, nausea, diarrhoea, blurred vision, headache, dizziness,
hypotension, photosensitisation hepatic dysfunction, hyperglycaemia and glycosuria,

rarely bone marrow depression, gynaecomastia, hirsutism, hoarseness, menstrual irregularities,
 loss of libido,impotence.

History of hypersensitivity, anuria or severe oliguria, hypovolaemia, hyponatraemia, hypotension,
urinary retention due to prostatic hypertrophy. Addison's disease, lactation, renal  impairment,
hyperkalaemia, acute or severe liver failure.

Special Precaution:
Concomittant use with ACE  inhibitors, monitor fluids and electrolytes including changes in serum
potassium levels, dilutional hyponatraemia or even a true low-salt syndrome may develop.
General anaethesia, pregnancy, lactation.

Refractory edema Hypertension associated with secondary hyperaldeosterronism

Dosage-

1- 4 tabs daily. Adjust dose after 10 days epending on response

Children- not recommended