Drug Interaction:
Calcium Channel Blockers include - Bepridil, Diltiazem, Felodipine, Isradipine, Nicardipine, Nifedipine, Nimodipine, Verapramil, Amlodipine, Nisodipine, Clevidipine, Lercandipine
Refer Verapramil-
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
Nicardipine Hcl Anti-hypertensive October 1993
Indication:
U.S.FDA APPROVED DRUGS FROM 01-01-08 TO 31-12-08
Drug name Indication Date of Approval
107. Nicardipine HCL injection 07-04-08
For short term treatment of hypertension when
oral therapy is not feasible or not desirable
Approved by FDA in December 1988
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
1.Nicardipine Hcl Anti-hypertensive October 1993
2.Nicardipine Hcl Inj 07-04-2008
2.5mg/ml
For Short-term treatment of Hypertension when oral therapy is not
feasible or not desirable
Chronic stable angina
Calcium Channel Blockers include - Bepridil, Diltiazem, Felodipine, Isradipine, Nicardipine, Nifedipine, Nimodipine, Verapramil, Amlodipine, Nisodipine, Clevidipine, Lercandipine
Refer verapramil-
Adverse Reaction:
NICRADIPINE-
Generally not serious, rarely requires discontinuation or dosage adjustment
CNS -
Dizziness/lightheadedness 6% , Headache 8%
Asthenia 5% Somnolence 2 %, Parathesia 1 %
GASTROINTESTINAL -
Nausea 2% Abdominal discomfort / cramps/dyspepsia 2 %,
Dry mouth/ thirst 1%
CARDIOVASCULAR-
Peripheral edema 8%,Angina 5%, Palpitation 4%, Syncope< 1%
DERMATOLOGIC-
Dermatitis/rash 1%
OTHER-
Flushing 9%,
Contra-Indications:
Refer - Verapramil- Calcium channel blockers
Dosages/ Overdosage Etc:
Approved by FDA in December 1988
Indications:
Chronic stable angina
Dosage:
Individualise dosage. Usual initial dose is 20mg 3 times/day (range 20 to 40mg 3 times/day) Allow at least 3 days before increasing dose to ensure acheivement of steady state plasma drug concentrations.
Patient Information:
Calcium channel blockers-
1.Take the medicine exactly as directed by the physician.
2.Swallow the tablet whole,without crushing or chewing it. However if advosed by the doctor, you may break into half.
3.Take the medicine with food or milk.
Pharmacology/ Pharmacokinetics:
Refer - Verapramil - Calcium channel blocker
Interaction with Food:
Refer- Verapramil - Calcium channel blocker
Pregnancy and lactation:
Refer - Verapramil - Calcium channel Blocker