Drug Interaction:
Calcium Channel Blockers include - Bepridil, Diltiazem, Felodipine, Isradipine, Nicardipine, Nifedipine, Nimodipine, Verapramil, Amlodipine, Nisodipine, Clevidipine, Lercandipine
Refer verapramil-
Indication:
Calcium Channel Blockers include - Bepridil, Diltiazem, Felodipine, Isradipine, Nicardipine, Nifedipine, Nimodipine, Verapramil, Amlodipine, Nisodipine, Clevidipine, Lercandipine
Refer verapramil-
Adverse Reaction:
ISRADIPINE
CNS-
Headache 14%, Dizziness/lightheadedness 7 %,Fatigue/lethargy 4 %
Weakness/shakiness, jitteriness 1 %, Drowsiness, Nervousness ,Psychiatric
disturbances, Depression, amnesia, paranoia, psychosis , hallucinations ,
Blurred vision , Parathesia,Insomnia, < 1 %
GASTROINTESTINAL -
Flatulence < 2 %, Nausea 2% Abdominal discomfort / cramps/dyspesia 2%,
Diarrhea, Vomiting 1%, Constipation, Dry mouth /thirst < 1%,
CARDIOVASCULAR-
Palpitation 42%,Periph.edema 7%, Angina 2%,Tachycardia 1.%
Hypotension,Syncope, Congestive Heart failure, Myocardial infarction, < 1%
DERMATOLOGICAL-
Dermatitis/rash 2%, Pruritis/urticaria < 1 %
HISTALOGICAL-
Leukopenia < 1%
OTHER-
Flushing 3%,Shortness of breath/dyspesia/wheezing 2%,
Mituration disoder,ployuria, nocturia, dysuria, frequency, sweating, Sexual difficulties, cough < 1%,
Contra-Indications:
Refer - Verapramil- Calcium channel blockers
Dosages/ Overdosage Etc:
Approved by FDA in December 1990
Indications:
Hypertension
Dosage:
Individualise dosage. Recommended initial dose is 2.5mg twice daily. Anantihypertensive response usually occurs within 2 to 3 hours.
Maximal response may require 2 to 4 weeks. If a satisfactory response does not occur after this period, dose may be adjusted in increments of 5mg.day at 2 to 4 week intervals upto a maximum of 20mg/day
Patient Information:
1.Take the medicine exactly as directed by the physician.
2.Swallow the tablet whole,without crushing or chewing it. However if advosed by the doctor, you may break into half.
3.Take the medicine with food or milk.
Pharmacology/ Pharmacokinetics:
Refer - Verapramil - Calcium channel Blocker
Interaction with Food:
Refer - Verapramil - Calcium channel Blocker
Pregnancy and lactation:
Refer - Verapramil - Calcium channel Blocker
