Nitrates include Amyl Nitrate, Nitroglycerin, Isosorbide dinitrate, Isosorbide mononitrate

Refer - Isorbide 5- mononitrate 

Other vasodilators,cal antagonists,ACE inhibitors,beta blkrs diuretics,antihypertensives, tricylic antidepressants,major tranquilisers may alter the effect

Alcohol may potentiate the blood pressure lowering effect of concurrently administered nitroglycerine Alcohol may produce severe hypotension and collapse.

Bioavailabilty of dihydroergometrine may be increased and may lead to coronary vasoconstriction.

Therapeutic response may be reduced by aspirin and NSAIDs.

Prophylaxis, treatment and management of angina 

Nitrates include Erythrityl tetranitrate, Isosorbide dinitrate, Isosorbide mononitrate, nitroglycerin , pentraerythritrol tetranitrate, glyceryl trinitrate

Refer - Isorbide 5- mononitrate

Headache(treat with mild analgesics if unbearable,failing which discontinue therapy). Reddening of skin,allergic contact dermititis.Mild local itching or burning sensation.Local irritation(change application site frequently)

Facial flushing,faintness,or light headedness,dizziness,postural hypotension,associated reflux-induced tachycardia.Nausea, vomiting(rare)

. I.V.administration: I.V.preparations contain substantial quantities of alcohol and reports of alcohol intoxification. Topical application: Contact dermatitis

Sub lingual/Buccal tablets: Localised burning sensation, delayed dissolution in dry mouth, rate of dissolution enhanced by hot liquids.Risk of aspiration.

Known htpersens to nitroglycerine and related organic nitrate compounds.Acute circulatory failure associated with marked hypotension.Conditions associated with elevated intracranial pressure. Myocardial insuffiency due to obstruction.

Special precautions:

Hypoxemia.Hypertrophic cardiomyopathy,increased angina and tolerance to sublingual nitroglycerine, renal/hepatic impairment,hypothyroidism.

Indications:

Sublingual Prophylaxis, treatment and management of angina

Dosage:

Dissolve 1 tablet under tongue or in buccal pouch (between cheek and gum ) at first sign of an acute anginal attack. Repeat every 5 minutes until relef is obtained.

Take no more than 3 tablets in 15 minutes. If pain continues, notify physician

Nitrates include Erythrityl tetranitrate, Isosorbide dinitrate, Isosorbide mononitrate, nitroglycerin , pentraerythritrol tetranitrate

Refer - Isorbide 5- mononitrate