Cyclosorine-                                                                                                               Coadministration with cyclosporine slightly increased  the steady-state AUC of anidulafungin by 22%

Hypersensitivity-                                                                                                           Possible histamine mediated ymptoms have been reported with antidulafingin including, flushing,hypotension,pruritis, rash and urticaria.                  

These reactions are infrequent when the rate of anidulafungin infusion does not exceed 1.1mg/min  

Candidemia/other Canida infections-                                                                              The following reactions ocurred in less than 2% of patients treated for candiderma/other infections in less than 1% of the patients treated for esophageal candidiasis and were judged by investigators to be at least possibly related to antidualafungin 

Cardiovascular-                                                                                                               Atrial fibrillation, bundle branch block.(right) electrocardiogram, early transition, electrocardiogram QT prolonged, flushing, hot flushes, hypertension,hypotension,sinus arrhythmia, thrombophebitis superficial, ventricular extrasystoles

CNS-                                                                                                                 Convulsions, dizziness, headache

Dermatologic-                                                                                                      Angioneurotic edema, erythemia, pruritus, pruritus generalized, sweating increased, urticaria 

GI-                                                                                                                                        Abdominal pain upper, constipation, diarrhea, dyspepsia, fecal incontinence, nausea, vomiting  

Haematologic/Lymphatic-                                                                               Coagulalopathy, thrombocytopenia

Hepatic-                                                                                                                                Abnormal liver function  tests,cholestaotasis, hepatic necrosis  

Metabolic/Nutrional-                                                                                                            Hypercalcemia, hyperglycemia, hyperkalemia, hypernatremia, hypomagnesmia

Musculoskeletal-                                                                                                                    Back pain, rigors

Ophthalmic-                                                                                                                          Eye pain,vision blurred, visual disturbances

Miscellaneous-                                                                                                         Candisiasis, clostridial infection, cough, fungemia, infusion-relared reactions,oral candiadiasis, peripheral edema                                                                                                                                   

Lab test abnormalities-                                                                                                      Amylase increased, bilirubin increased, creatine phosphokinase increased, creatinine  increased, gamma glutamyl transferase increased, lipase increased, magnesium decreased, platelet count decreased, platelet countecreased increased, potassium decreased, prothrombin time prolonged, urea increased                                                                               

Contraindications-                                                                                                                     Known hyperssensitivity to anidulafungin, to any of its components, or to other echinocandins 

Warnings/Precautions-                                                                                                       Hepatic effects-  Laboratory abnormalities in liver function tests have been seen in healthy volunteers   and patients with anidulfulgin

Monitor  patients who develop abnormal liver function tests during anidulafungin therapy   for evidence of worsening of hepatic function and avaluate risk/benefit of continuing anidulafungin therapy   

 Pregnancy-                                                                                                                         There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, use anidulafungin during pregnancy only if the potential benefit justifies the risk to the uterus.                       

 Lactation-                                                                                                                             Administer  to breast-feeding mothers only if the potential benefit justifies the rifsk.Anidulafungin was found in the milk of lactating rats. It is not known whether  Anidulafungin is excreted in human milk

Children-                                                                                                                                Safety and efectiveness of anidulafungin in children have not been established                                                                                                                                                              Monitoring-                                                                                                                             Monitor patients who develop abnormal liver function tests during Anidulafungin therapy for evidence of worsening hepatic failure

Advise patients that this medicine only works against fungus, it does not treat viral infections eg.common cold

Be sure to tell patients to use this medicine for full course of treatment. If they do not this medicine may not clear up the infection completely

Instruct patients to notify their healthcare provider if any of the following common adverse reactions persist or become bothersome; diarrhea,headache, pain,swelling,or redness at the injection site.

Instruct patients to seek medical attention right away if any of the following severe adverse reactions occur, severe allerlgic reactions-( rash,hives,itching, difficulty breathing, tightness in the chest,swelling of the mouth,face,lips,tounge,unusual hoarness), dark urine,fever, chills,or persistent sore , irregular heartbeat, leg redness,swelling or pain,pale stools,seizures,severe or persistent stomach pain,shotness of breath,unsual brusing or bleeding, yellowing of the skin or eyes

Pregnancy-                                                                                                                         There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, use anidulafungin during pregnancy only if the potential benefit justifies the risk to the uterus.                       

 Lactation-                                                                                                                             Administer  to breast-feeding mothers only if the potential benefit justifies the rifsk.Anidulafungin was found in the milk of lactating rats. It is not known whether  Anidulafungin is excreted in human milk

Children-                                                                                                                                Safety and efectiveness of anidulafungin in children have not been established