Patient Information:
        
        
            
	Ref - USP PDI Vol II 17th Edition (1997)
	 
	TRIMETREXATE- SYSTEMIC
	 
	1.Allergies-
	  Tell your doctor if you have ever had any unusual or allergic reaction to 
	   Timetrexate, metrexate or leucovorin. Also tell your healthcare care
	   professional if you are allergic to any other substances such as foods,
	   preservatives or dyes.
	 
	2.Pregnancy- 
	   Use of trimetrexate during pregnancy should be avoided whenever 
	   possible since trimethotrexate has  caused birth defects of the fetus in 
	   animal studies. Use of birth control is recommended during trimethrexate
	   therapy. Tell your doctor if you think you are pregnant or if you need advice
	   on birth control    
	 
	3. Breast-feeding-
	    It is not known whether trimetrexate  passes into breast milk. However,
	     breast feeding should be stopped during treatment  with this medicine,
	     since the medicine may cause unwanted effects on nursing babies
	 
	4.Children-
	    This medicine has been tested in a limited number of children younger than
	    18 years of age. Trimetrexate can cause serious side effects in any patient.  
	     However, in  effective doses this  medicine did not cause  different side effects
	     or   problems than it does in adults.
	 
	5.Older adults- 
	   There is no specific information  comparing use of  trimetrexate  in the elderly
	    with use   in other age groups. 
	 
	6. Other medicines-
	     When you are taking trimetrexate it is especially important that your doctor
	     know if you are taking any of the following-
	 
	     Acetoaminophen or
	     Amiodarone or
	     Anabolic steroids or
	    Androgens or
	    Carbamazepine or
	    Dantrolene or
	    Estrogens or
	    Hydroychloroquine or
	    Methyldopa or
	    Use of these medicines may increase the chance of side effects
	 
	7. Other medical problems-
	   The presence of other medical problems may affect the use of 
	    trimetrexate.  Make sure   you tell your doctor if you have any other
	    medical problems especially-
	 
	    Anemia or
	    Low platelet count or
	    Low white blood cell count - trimetrexate may make the blood diseases
	    you have worse.
	    Kidney disease or
	    Liver disease - kidney or liver disease may increase the chance of
	    side effects from trimetrexate