Drug Interaction:
Ornidazole when administered along with oral anti-coagulants may increase the
risk of hemorrhage and prolongs the muscle relaxation efffect of Vercueonium bromide
Cefixine increase the prothrombin time of warfarin and other anticoagulants
Indication:
Intra-abdominal Infections
Gastroenteritis,
Amoebic dysentry
Dental and Gynaecological infections
Adverse Reaction:
Headache, nausea, vomiting, dizziness, peripheral neuropathy
Pruritus, candiadiasis, nephrotoxicity
Contra-Indications:
Headache, nausea, vomiting, dizziness, peripheral neuropathy
Pruritus, candiadiasis, nephrotoxicity
Dosages/ Overdosage Etc:
Intra-abdominal Infections
Gastroenteritis,
Amoebic dysentry
Dental and Gynaecological infections
Dosage-
As prsecribed by the physician
Each blister pack contains cefixime 200mg and ornidazole 500mg in a blister
pack of 10s.
Pharmacology/ Pharmacokinetics:
Pharmacodynamics-
Cefixime inhibits thge cell wall synthesis of both gram-positive and gram-negative
bacteria,it mainly acts by inhibiting a bacterial enzyme namely transpeptidase
which is necessary for cross linking of peptidoglycan chain to form rigid wall cells
Ornidazoleacts by inhibiting protein synthesis among the susceptible organisms.
The drug enter the cell by diffusion . the redox proteins in the anaerobes reduces the
nitro group of the drug into nitro radical which damages the DNA and other important
biomolecules of the organism by cytotoxic action
Pharmacokinetics-
Cefixiine is absorbed upto 50% when administered orally. The peak serum
concentration is attained withi 2-6 hours after administration. The drug is
distributed widely in the body . It is 60-70% plasma protein bound.
Only a portion of the drug is metabolised and excreted through urine
Ornidazole is readily absorbed by oral administration. The peak plasma
concentration is attained after 2 hours of administration. It is widely distributed
in the body tissue and the cerbrospinal fluid. The drug is < 15% bound to plasma
protein and is excreted via urine and feces
