Potentiates diuretic action of frusemide.

Efficacy increased when given combination of beta-blckrs, reduces lithium clearance, hence dose should be reduced if given concurrently with clopamide.

Reduces effect of oral anticoagulants and hypoglycaemics agents.

Hypertension

No deaths reported. However in combination with peridol may cause marked hypotension and acute coronary insufficiency in hypertensives.

Hypokalemia(esp in combin with diuretics) Hyperglycaemia may precipitate gout.

Sports events- restricted/banned

Acute glomerulonephritis,severe renal and hepatic failure or resistent hypokaleamia,  Hypersens to sulphonamide-type medication,hypocalcemia Addisons disease, pregnancy,breast feeding.

Special precautions:

Increased sensitivity of elderly to diuretics, possible electrolyte imbalance In hypokalaemia a potassium rich diet, potassium supplement or potassium sparing drug may be indicated in digitalized patients, diabetic patients, patients suffering from gout,renal failure, dilutional hyponatraemia in odematous patients.

Indication

Hypertension

Edema

Dosage-

Hypertension- 5 -20mg daily edema - 10- 80mg daily Both in the morning

Tablets to be taken in the morning

Pregnancy,breast feeding patients - contra-indicated