Amifampridine- (BNF)- Neuromuscular drug
Drug Name:
Amifampridine- (BNF)- Neuromuscular drug
List Of Brands:
Indication Type Description:
Indication:
Ref- BNF (British National Formulary- March 2015)
(Specialists Use only) Symptomatic treatment of Lambert- Eaton myasthenic
syndrome
Adverse Reaction:
Side effects-
Gastro-intestinal disorders, parasthesia. palpitations, arrthythmias,
Raymonds Syndrome
Cough, bronchial hyposecretion, excerbation or precipation of asthma.
Sleep disturbances, convulsions, anxiety, drowsiness, dizziness. weakness
Headache, chorea, myoclonia, and blurred vision also reported
Contra-Indications:
Contraindications-
Epilepsy , unconcontrolled asthma , congenital QT syndrome .
Avoid concomittant use of drugs that prolong QT interval
Avoid concomittant use of drugs with a narrow therapeutic index.
Hepatic Impairment- Use with caution
Renal impairment - Use with caution
Caution-
Concomittant use of drugs that lower convulsive threshold,non-pareneoplastic
form of Lambert-Eaton myasthenic syndrome clinical and ECG monitoring
required at treatment initiation and yearly thereafter
Dosages/ Overdosage Etc:
Ref- BNF (British National Formulary- March 2015)
BRAND - FIRDAPSE -
MANUFACTURER - BIO-MARIN
BIO MERIN EUROPE LTD.
TEL (020) 74200800
biomarin-europe@bmrn.com
Indications-
(Specialists Use only) Symptomatic treatment of Lambert- Eaton myasthenic
syndrome
Dosage-
Adult- over 18 years 15mg daily in 3 divided doses
Increased in steps of 5mg every 4.5 days to max.50mg daily
in 3-4 divided doses
Maximum single dose 20mg
Hepatic Impairment-
Use with caution
In mild impairment
reduce initial dose to 10mg daily in divided doses.
Increase in steps of 5mg every 7 days
In moderate or severe impairment
reduce initial dose to 5mg in divided doses,
increased in steps of 5mg every 7 days
Renal impairment -
Use with caution
In mild impairment
reduce initial dose to 10mg daily in divided doses
increased in steps of 5mg every 7 days
In moderate to severe impairment
reduce initial dose to 5mg daily individed doses
increased in steps of 5mg every 7 days
Pregnancy and lactation:
Pregnancy-
Manufacturer advices, avoid- ensure effective ontraception during treatment
in men and women
Breast feeding-
Manufacturer advices avoid- no information available