Adverse Reaction:
Side effects-
loss of appetite, weight loss, taste disturbances, diarrhoea,
constipation, abdominal pain dyspepsia, dry mouth,
abnormal liver finction tests, cardiac toxicity and disorders,
tachycardia, hypotension, pallor, vein discoloration,
odema, dyspnoea, cough, drowsiness, malaise, headache,
paraesthesia, infection, pyrexia, biochemical and electrolyte
disturbances, chromaturia. haematuria, bone pain,
conjuntivitis, skin discoloration, pruritus, nail disorder,
less commonly, oesophagitis, rectal haemorrhage,
arrhythmia, vein disorder, pleural effuson, pneumonitis,
rhinorrhoea, enxiety sleep disorder, dizziness, vertigo,
spontaneous erection, tumor progression, oliguria,
arthalgia, arthitis, musculoskeletal pain and weakness,
dry eye, keratitis, night seats, petechiae, skin ulcer, rash
Contra-Indications:
Contraindication-
immunization with live virus vaccines , active severe infection or
risk factors severe infection
Cautions-
history of active cardiovascular disease, previuos therapy with
anthracyclines or antthracenediones, previous or concurrent
radiotherapy to the intestinal area, or concurrentuse of
cardiotoxic drugs, increased cardiotoxicity
Hepatic impairment-
no information available - manufacturer advices caution in mild to
moderate impairment, avoid in severe impairment
Renal impairment-
no information available- manufacturer advices caution