Hypertension 

Antiadrenergic agents ( Peripherally acting )include- Reserpine, Guanithidine monosulphate, Guandrel sulfate, ( Alpha-1- blockers), Prazosin,Terazosin, Doxazosin, Tamsulosin, Silodosin, Alfuzosin Hcl Refer - Prazosin 

Date of Approval        June 1972

Indications:

Hypertension

Dosage:

Hypertension- patients not receiving other antihypertensive agents- usual dosage is 0.5mg daily for 1 or 2 weks.

Maintenance- reduce to 0.1 to 0.25mg daily. Use higher doses cautiously because occurance of serious mental depression and other side effects may increase considerably.

Overdosage- Symptoms No deaths due to acute poisioning with reserpine have been reported. Highest known doses survived impairment of consciousness may occur and may range of overdosage. Flushing of the skin, conjuntivial injection and pupilary constriction are to be expected Hypotension hyperhermia,central respiratory depression and beadycardia may develop in cases of severe overdosage. Increased salivary secretion gastric secretion and diarrhea may also occur .

Treatment

1.There is no specific antidote

 2. Evacuate stomach contents,taking adequate precautions against aspiration and for protection of the airway. 3. Activate charcoal slurry should be instilled 4.Treat the effects of resperpine overdosage symptomaticaly 5.If hypotensionis severe enough to require treatment with vasopressor use one having a direct action upon vascular smooth muscle e.g. phenylephirine , nor epinneprine, metaraminol ) 6. Since reserpine is long acting, observe the patient carefully for at least 72 hours. and administer treatment as required.

Missed dose

1. If you miss a dose of this medicine, do not take the missed dose at all.

2. Do not double the next dose.

3. Instead, back to your regular dosing schedule.

Nasal congestion- Drugs causing advesse reactions- ( 386 )

1. Reserpine

2. Guanethidine

3. Isopreternol

4. Oral contraceptives

5. Decongestant abuse 

Peptic ulceration -

Drugs causing Adverse Reactions- ( 385 )

1. Aspirin

2. Phenylbutazone

3. Indomethicin

4. Ethacrynic acid

5. Reserpine ( latge doses ) 

Drowsiness-

Drugs causing adverse reactions- ( 388 )

1. Anxiolytic drugs

2. Major tranquillizers

3. Tricyclic antidepressants

4. Antihistamines

5. Methyldopa

6. Clonidine

7. Reserpine

1. Inform patients of possible side effects and advice them to take medication regularly and continously as directed

 Antiadrenergic agents ( Peripherally acting )include- Reserpine, Guanithidine monosulphate, Guandrel sulfate, ( Alpha-1- blockers), Prazosin,Terazosin, Doxazosin, Tamsulosin, Silodosin, Alfuzosin Hcl Refer - Prazosin 

Pharmacology:

Resrpine depletes stores of catecholamine and 5-hydroxytryptamine in many organs including brain and adrenal medulla. The depression of sympathetic nerve function results in decreased heart rate and lowering of arterial blood pressure. The sedative and tranquilising properties of reserpine are thought to be related to depletion of catecholamine and 5-hydroxytyptamine from the brain.

Pharmacokinetics:

Reserpine is characterised by slow onset of action and sustained effects. Both cardiovascular and CNS effects may persist for a period of time folowing withdrawal of the drug. Plasma levels of reserpine after IV administration declined with a mean half-life of 33 hours. reserpine is extensively bound to plasm proteins.

None reported.

Pregnancy:

Use during pregnancy only if the potential benefits justifies the potential risk to the fetus.

Lactation:

Use with caution and decide whether to discontinue nursing or discontinue the drug taking into consideration the importance of the drug to the mother.

Children- Safety and efficacy for use in children have not been established.